Search: WFRF:(Pino J)
> (2020-2024) >
Dicer ablation in K...
Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice
-
Roa, J. (author)
-
Ruiz-Cruz, M. (author)
-
Ruiz-Pino, F. (author)
-
show more...
-
Onieva, R. (author)
-
Vazquez, M. J. (author)
-
Sanchez-Tapia, M. J. (author)
-
Ruiz-Rodriguez, J. M. (author)
-
Sobrino, V. (author)
-
Barroso, A. (author)
-
Heras, V. (author)
-
Velasco, I. (author)
-
Perdices-Lopez, C. (author)
-
- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
-
Avendano, M. S. (author)
-
Prevot, V. (author)
-
- Poutanen, Matti (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
-
Pinilla, L. (author)
-
Gaytan, F. (author)
-
Tena-Sempere, M. (author)
-
show less...
-
(creator_code:org_t)
- 2022-08-09
- 2022
- English.
-
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Kiss1 neurons, producing kisspeptins, are essential for puberty and fertility, but their molecular regulatory mechanisms remain unfolded. Here, we report that congenital ablation of the microRNA-synthesizing enzyme, Dicer, in Kiss1 cells, causes late-onset hypogonadotropic hypogonadism in both sexes, but is compatible with pubertal initiation and preserved Kiss1 neuronal populations at the infantile/juvenile period. Yet, failure to complete puberty and attain fertility is observed only in females. Kiss1-specific ablation of Dicer evokes disparate changes of Kiss1-cell numbers and Kiss1/kisspeptin expression between hypothalamic subpopulations during the pubertal-transition, with a predominant decline in arcuate-nucleus Kiss1 levels, linked to enhanced expression of its repressors, Mkrn3, Cbx7 and Eap1. Our data unveil that miRNA-biosynthesis in Kiss1 neurons is essential for pubertal completion and fertility, especially in females, but dispensable for initial reproductive maturation and neuronal survival in both sexes. Our results disclose a predominant miRNA-mediated inhibitory program of repressive signals that is key for precise regulation of Kiss1 expression and, thereby, reproductive function. Kiss1 neurons are essential for puberty and fertility. Here, the authors show that canonical microRNA biosynthesis in Kiss1 neurons plays an essential role in the control of puberty and fertility, especially in females, likely via repression of repressors on the Kiss1 gene.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- positive feedback action
- hormone secretion
- arcuate nucleus
- neurokinin-b
- hypothalamic expression
- kisspeptin neurons
- metabolic-control
- system
- reproduction
- roles
- Science & Technology - Other Topics
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Roa, J.
-
Ruiz-Cruz, M.
-
Ruiz-Pino, F.
-
Onieva, R.
-
Vazquez, M. J.
-
Sanchez-Tapia, M ...
-
show more...
-
Ruiz-Rodriguez, ...
-
Sobrino, V.
-
Barroso, A.
-
Heras, V.
-
Velasco, I.
-
Perdices-Lopez, ...
-
Ohlsson, Claes, ...
-
Avendano, M. S.
-
Prevot, V.
-
Poutanen, Matti
-
Pinilla, L.
-
Gaytan, F.
-
Tena-Sempere, M.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
- Articles in the publication
-
Nature Communica ...
- By the university
-
University of Gothenburg