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  • Zheng, Ju ShengMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom; Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China,University of Cambridge (författare)

Plasma Vitamin C and type 2 diabetes : Genome-wide association study and mendelian randomization analysis in European populations

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2020-11-17
  • American Diabetes Association,2021
  • 9 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:063a1e11-fbd6-44ef-9d99-c85911fd65c0
  • https://lup.lub.lu.se/record/063a1e11-fbd6-44ef-9d99-c85911fd65c0URI
  • https://doi.org/10.2337/dc20-1328DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-186194URI

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  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • OBJECTIVE Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with type 2 diabetes. RESEARCH DESIGN AND METHODS We conducted genome-wide association studies of plasma vitamin C among 52,018 individuals of European ancestry to discover novel genetic variants. We performed Mendelian randomization analyses to estimate the association of genetically predicted differences in plasma vitamin C with type 2 diabetes in up to 80,983 case participants and 842,909 noncase participants. We compared this estimate with the observational association between plasma vitamin C and incident type 2 diabetes, including 8,133 case participants and 11,073 noncase participants. RESULTS We identified 11 genomic regions associated with plasma vitamin C (P < 5 ☓ 10-8), with the strongest signal at SLC23A1, and 10 novel genetic loci including SLC23A3, CHPT1, BCAS3, SNRPF, RER1, MAF, GSTA5, RGS14, AKT1, and FADS1. Plasma vitamin C was inversely associated with type 2 diabetes (hazard ratio per SD 0.88; 95% CI 0.82, 0.94), but there was no association between genetically predicted plasma vitamin C (excluding FADS1 variant due to its apparent pleiotropic effect) and type 2 diabetes (1.03; 95% CI 0.96, 1.10). CONCLUSIONS These findings indicate discordance between biochemically measured and genetically predicted plasma vitamin C levels in the association with type 2 diabetes among European populations. The null Mendelian randomization findings provide no strong evidence to suggest the use of vitamin C supplementation for type 2 diabetes prevention.

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Luan, Jian’AnMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (författare)
  • Sofianopoulou, EleniBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cam-bridge, United Kingdom (författare)
  • Imamura, FumiakiMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (författare)
  • Stewart, Isobel D.Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (författare)
  • Day, Felix R.Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (författare)
  • Pietzner, MaikMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (författare)
  • Wheeler, EleanorMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (författare)
  • Lotta, Luca A.Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (författare)
  • Gundersen, Thomas E.Vitas AS,Vitas Ltd, Oslo, Norway (författare)
  • Amiano, PilarMinistry of Health of the Basque Government, Public Health Division of Gipuzkoa, Biodonostia Health Research Institute, Donostia-San Sebas-tian, Spain (författare)
  • Ardanaz, EvaNavarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; CIBER in Epidemiology and Public Health (CI-BERESP), Madrid, Spain,Navarre Public Health Institute (ISPN),Health Research Institute of Navarra (IDISNA)(Swepub:lu)extLU-05 (författare)
  • Chirlaque, María DoloresCIBER in Epidemiology and Public Health (CI-BERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, Instituto Murciano de Investigatión Bio-sanitaria (IMIB)-Arrixaca, Murcia University, Mur-cia, Spain,University of Murcia (författare)
  • Fagherazzi, GuyDigital Epidemiology and e-Health Research Hub, Department of Population Health, Luxembourg Institute of Health, Strassen, Luxembourg, France; Center of Epidemiology and Population Health, UMR 1018, INSERM, Paris South-Paris Saclay University, Gustave Roussy Institute, Villejuif, France,Institut Gustave Roussy,University of Paris-Saclay (författare)
  • Franks, Paul W.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Department of Clinical Sciences, Lund Univer-sity, Malmö, Sweden(Swepub:lu)med-plf (författare)
  • Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Laouali, NasserCenter of Epidemiology and Population Health, UMR 1018, INSERM, Paris South-Paris Saclay University, Gustave Roussy Institute, Villejuif, France,Institut Gustave Roussy (författare)
  • Mancini, Francesca RomanaCenter of Epidemiology and Population Health, UMR 1018, INSERM, Paris South-Paris Saclay University, Gustave Roussy Institute, Villejuif, France,Institut Gustave Roussy (författare)
  • Nilsson, Peter M.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Department of Clinical Sciences, Lund Univer-sity, Malmö, Sweden(Swepub:lu)medf-pni (författare)
  • Charlotte Onland-Moret, N.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands,Utrecht University (författare)
  • Olsen, AnjaDanish Cancer Society Research Center, Copen-hagen, Denmark; Department of Public Health, Aarhus Univer-sity, Aarhus, Denmark,Aarhus University (författare)
  • Overvad, KimDepartment of Public Health, Aarhus Univer-sity, Aarhus, Denmark; Department of Cardiology, Aalborg University Hospital, Aarhus, Denmark,Aalborg University Hospital (författare)
  • Panico, SalvatoreDipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy (författare)
  • Palli, DomenicoCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, Italy (författare)
  • Ricceri, FulvioAzienda Sanitaria Locale Torino 3,Department of Clinical and Biological Sciences, University of Turin, Turin, Orbassano, Italy; Unit of Epidemiology, Regional Health Service ASL TO3, Turin, Grugliasco, Italy (författare)
  • Rolandsson, OlovUmeå universitet,Umeå University,Allmänmedicin(Swepub:umu)olro0005 (författare)
  • Spijkerman, Annemieke M.W.National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands (författare)
  • Sánchez, María JoséAndalusian School Of Public Health (EASP),Andalusian School of Public Health, Granada, Spain (författare)
  • Schulze, Matthias B.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany; Institute of Nutrition Science, University of Potsdam, Nuthetal, Germany,German Center for Diabetes Research,University of Potsdam (författare)
  • Sala, NúriaUnit of Nutrition and Cancer, Cancer Epidemiology Research Program and Translational Research Laboratory, Catalan Institute of Oncology-ICO, Group of Research on Nutrition and Cancer, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet of Llobregat, Barcelona, Spain,Catalan Institute of Oncology,L'Hospitalet de Llobregat, Barcelona (författare)
  • Sieri, SabinaEpidemiology and Prevention Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori di Milano Via Venezian, Milan, Italy,British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cam-bridge, United Kingdom; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom; National Institute for Health Research Cambridge Biomedical Research Center, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom; Health Data Research UK Cambridge, Well-come Genome Campus and University of Cam-bridge, Cambridge, United Kingdom,Wellcome Trust Sanger Institute (författare)
  • Tjønneland, AnneDepartment of Public Health, Aarhus Univer-sity, Aarhus, Denmark; Institute of Public Health, University of Copen-hagen, Copenhagen, Denmark,University of Copenhagen (författare)
  • Tumino, RosarioCivic and M.P Arezzo Hospital,Cancer Registry and Histopathology Depart-ment, Azienda Sanitaria Provinciale (ASP), Ra-gusa, Italy (författare)
  • van der Schouw, Yvonne T.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands,University Medical Center Utrecht (författare)
  • Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization,International Agency for Research on Cancer, Lyon, France (författare)
  • Riboli, ElioSchool of Public Health, Imperial College, London, United Kingdom (författare)
  • Danesh, JohnBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cam-bridge, United Kingdom; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom; British Heart Foundation Center of Research Excellence, University of Cambridge, Cambridge, United Kingdom; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom; National Institute for Health Research Cambridge Biomedical Research Center, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom; Health Data Research UK Cambridge, Well-come Genome Campus and University of Cam-bridge, Cambridge, United Kingdom,Wellcome Trust Sanger Institute (författare)
  • Butterworth, Adam S.Wellcome Trust Sanger Institute,University of Cambridge (författare)
  • Sharp, Stephen J.Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (författare)
  • Langenberg, ClaudiaMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (författare)
  • Forouhi, Nita G.Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (författare)
  • Wareham, Nicholas J.Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (författare)
  • Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom; Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, ChinaUniversity of Cambridge (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Diabetes Care: American Diabetes Association44:1, s. 98-1060149-59921935-5548

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