Modulation of early immune responses and suppression of Trypanosoma brucei brucei infections by surgical denervation of the spleen

• <i>Objective:</i> To examine critical interactions between the nervous system and the immune system during experimental African trypanosomiasis. <i>Methods and Results:</i> Inoculation of <i>Trypanosoma brucei brucei </i>resulted in early interferon (IFN)-γ production, elevated corticosterone and prostaglandin E₂ (PGE₂) levels and increased splenocyte proliferation, as measured by enzyme-linked immunospot assay, radioimmunoassay and thymidine incorporation assay, respectively. Splenic denervation suppressed IFN-γ, corticosterone and PGE₂ production, enhanced splenocyte proliferation, and significantly reduced parasitemia and prolonged rat survival. <i>Conclusions:</i> Our data show substantial effects of the nervous system on early immune responses that may influence the outcome of this disease. These effects were not dependent on cytokine inhibitory mediators such as prostaglandins or stress hormones. More investigations are required to understand the evident neural control over the immune system during infectious challenges, which may assist in novel therapeutic approaches.

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