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Splenic denervation...
Splenic denervation suppresses mRNA gene expression and protein production of IL-1beta and IL-6 by peritoneal macrophages in both Trypanosoma brucei brucei-infected and non-infected rats
- Artikel/kapitelEngelska2004
Förlag, utgivningsår, omfång ...
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2004-02-06
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S. Karger AG,2004
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:1928519
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1928519URI
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https://doi.org/10.1159/000075320DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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<i>Objective:</i> To test the hypothesis that the nervous system participates in modulating the immune response during experimental African trypanosomiasis caused by <i>Trypanosoma brucei brucei</i>. <i>Methods and Results:</i> Using in situ hybridization and immunochemistry, we studied the effects of splenic sympathectomy on mRNA gene expression and protein production of IL-1β and IL-6 in splenic and peritoneal macrophages (PMΦ) of Sprague-Dawley rats infected with <i>T. brucei brucei</i> and non-infected rats. The enhancements of mRNA gene expression and production of IL-1β and IL-6 by peritoneal macrophages were significantly suppressed by the splenic sympathectomy in both infected and non-infected rats. <i>Conclusions:</i> Our data indicate a probably stimulatory role of the sympathetic nervous system during the host immune response in both normal and <i>T. brucei brucei</i>-infected rats.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Li, ZLKarolinska Institutet
(författare)
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Svaren-Quiding, C
(författare)
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Cui, JG
(författare)
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Ozenci, VKarolinska Institutet
(författare)
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Bakhiet, M
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Neuroimmunomodulation: S. Karger AG11:2, s. 113-1181021-74011423-0216
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