Sökning: (WFRF:(Li P. L.)) srt2:(1995-1999) >
Impairment of synap...
Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice
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LI, L (författare)
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CHIN, LS (författare)
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- SHUPLIAKOV, O (författare)
- Karolinska Institutet
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- BRODIN, L (författare)
- Karolinska Institutet
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SIHRA, TS (författare)
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HVALBY, O (författare)
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JENSEN, V (författare)
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ZHENG, D (författare)
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MCNAMARA, JO (författare)
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GREENGARD, P (författare)
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ANDERSEN, P (författare)
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(creator_code:org_t)
- 1995-09-26
- 1995
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 92:20, s. 9235-9239
- Relaterad länk:
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http://www.pnas.org/...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Synapsin I has been proposed to be involved in the modulation of neurotransmitter release by controlling the availability of synaptic vesicles for exocytosis. To further understand the role of synapsin I in the function of adult nerve terminals, we studied synapsin I-deficient mice generated by homologous recombination. The organization of synaptic vesicles at presynaptic terminals of synapsin I-deficient mice was markedly altered: densely packed vesicles were only present in a narrow rim at active zones, whereas the majority of vesicles were dispersed throughout the terminal area. This was in contrast to the organized vesicle clusters present in terminals of wild-type animals. Release of glutamate from nerve endings, induced by K+,4-aminopyridine, or a Ca2+ ionophore, was markedly decreased in synapsin I mutant mice. The recovery of synaptic transmission after depletion of neurotransmitter by high-frequency stimulation was greatly delayed. Finally, synapsin I-deficient mice exhibited a strikingly increased response to electrical stimulation, as measured by electrographic and behavioral seizures. These results provide strong support for the hypothesis that synapsin I plays a key role in the regulation of nerve terminal function in mature synapses.
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- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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LI, L
-
CHIN, LS
-
SHUPLIAKOV, O
-
BRODIN, L
-
SIHRA, TS
-
HVALBY, O
-
visa fler...
-
JENSEN, V
-
ZHENG, D
-
MCNAMARA, JO
-
GREENGARD, P
-
ANDERSEN, P
-
visa färre...
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Karolinska Institutet