WFRF:(Kristal BS)
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- Sheu, KFR (author)
A DLST genotype associated with reduced risk for Alzheimer's disease
- Article/chapterEnglish1999
Publisher, publication year, extent ...
- 1999-04-01
- Ovid Technologies (Wolters Kluwer Health),1999
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- LIBRIS-ID:oai:prod.swepub.kib.ki.se:1929053
- http://kipublications.ki.se/Default.aspx?queryparsed=id:1929053URI
- https://doi.org/10.1212/wnl.52.7.1505DOI
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- Language:English
- Summary in:English
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Notes
- Article abstract Recent studies suggest that variants of the DLST gene alter the risk of AD. DLST encodes the core subunit of the mitochondrial α-ketoglutarate dehydrogenase complex, which is deficient in AD. The authors report that in 247 US white subjects, homozygosity for DLST A19,117, T19,183 was associated with a reduced risk of AD (odds ratio [OR] = 0.35, p = 0.018). The reduced risk was marked in subjects who did not carry the apolipoprotein (APOE)-4 allele (OR = 0.16, p = 0.014). Further study of DLST in AD appears warranted.
Added entries (persons, corporate bodies, meetings, titles ...)
- Brown, AM (author)
- Kristal, BS (author)
- Kalaria, RN (author)
- Lilius, LKarolinska Institutet (author)
- Lannfelt, L (author)
- Blass, JP (author)
- Karolinska Institutet (creator_code:org_t)
Related titles
- In:Neurology: Ovid Technologies (Wolters Kluwer Health)52:7, s. 1505-15070028-38781526-632X
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