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Differential humora...
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Gabrielli, A
(författare)
Differential humoral immune response against hepatitis C virus antigenic synthetic peptides in infected patients with and without mixed cryoglobulinaemia
- Artikel/kapitelEngelska1996
Förlag, utgivningsår, omfång ...
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2003-10-29
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Oxford University Press (OUP),1996
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:1936033
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1936033URI
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https://doi.org/10.1046/j.1365-2249.1996.d01-720.xDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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In this study we have evaluated the prevalence of antibodies against core region peptides (residues 1–28, 21–38 and 51–68), the envelope 1, the non-structural (NS) 4 and 5 proteins of hepatitis C virus (HCV) in sera from 65 chronically HCV-infected patients, 47 with mixed cryoglobulinaemia (MC+) and 18 without (MC−). The major binding sites were located within the core region. Regions 1–28 and 51–68 were recognized by a similar proportion of MC+ and MC− patients, while peptide 21–38 was less frequently detected by samples from MC+ patients (65.5% versus 100%; P=0.011). The patterns of the reactions showed a minimum of three binding sites: one, located within region 51–68, was shared by both groups; a second determinant was identified at residues 1–21 for MC+ patients and at residues 28–38 for MC− patients; a third, not exactly localized, lay between residues 1 and 38. Recognition of NS5 peptides was not significantly different between MC+ and MC− patients, but while the former mostly reacted either with peptide 1 (residues 2294–2309) (five of 15 sera) or with peptide 2 (residues 2304–2319) (nine of 15 sera), the latter group showed a more scattered reaction. Antibodies to HCV peptides prevalently belonged to IgG1 subclass. However, whereas IgG1 antibodies against peptide 21–38 and peptide 1 of NS5 were more frequently found in MC− rather than in MC+ patients (100% versus 63.8%, P=0.003, and 22.2% versus 4.2%, P=0.025, respectively), IgG3 antibodies against region 1–28 were more frequent in MC+ patients (53.19% versus 16.6%, P=0.0078). Overall, the data suggest that a differential humoral immune response to HCV antigens occurs in patients with and without cryoglobulinaemia.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Zhang, ZX
(författare)
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Cherubini, G
(författare)
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Candela, M
(författare)
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Savoldi, S
(författare)
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Manzin, A
(författare)
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Clementi, M
(författare)
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Amoroso, A
(författare)
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Sallberg, MKarolinska Institutet
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinical and experimental immunology: Oxford University Press (OUP)105:1, s. 59-640009-91041365-2249
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