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A rat model for sev...
A rat model for severe limb ischemia at rest
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- Lundberg, G (författare)
- Karolinska Institutet
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Luo, F (författare)
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Blegen, H (författare)
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Kalin, B (författare)
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- Wahlberg, E (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2003-08-28
- 2003
- Engelska.
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Ingår i: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. - : S. Karger AG. - 0014-312X. ; 35:5, s. 430-438
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- We sought an animal model able to discriminate metabolic and angiogenic processes in limb ischemia. For that we modified and evaluated a rat model of severe unilateral limb ischemia at rest. A two-stage surgical procedure entailing left femoral artery ligation preceded by interruption of collateral vessels originating from the infra-renal aorta and left iliac arteries was performed in Sprague-Dawley rats. The model was evaluated for up to 8 weeks with a transit-time flow meter, a laser Doppler perfusion imager, microspheres, arteriography and histology. It was found to be well tolerated with low mortality and perfusion in the foot skin was reduced up to 8 weeks, while collaterals were visible after 2 weeks. Histologic signs of ischemia were seen for up to 4 weeks. This rat model of severe limb ischemia at rest lasts up to 8 weeks and seems well suited for longitudinal studies of the pathophysiology of limb ischemia and healing mechanisms like angio- and arteriogenesis.
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