Sökning: (L773:0012 1797 OR L773:1939 327X) srt2:(2005-2009)
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The CIDEA gene V115...
The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects
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- Dahlman, I (författare)
- Karolinska Institutet
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Kaaman, M (författare)
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- Jiao, H (författare)
- Karolinska Institutet
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- Kere, J (författare)
- Karolinska Institutet
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Laakso, M (författare)
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- Arner, P (författare)
- Karolinska Institutet
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(creator_code:org_t)
- American Diabetes Association, 2005
- 2005
- Engelska.
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 54:10, s. 3032-3034
- Relaterad länk:
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http://diabetes.diab...
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http://kipublication...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- The cell death–inducing DFFA (DNA fragmentation factor-α)-like effector A (CIDEA) gene is implicated as an important regulator of body weight in mice and humans and is therefore a candidate gene for human obesity. Here, we characterize common CIDEA gene polymorphisms and investigate them for association with obesity in two independent Swedish samples; the first comprised 981 women and the second 582 men. Both samples display a large variation in BMI. The only detected coding polymorphism encodes an exon 4 V115F amino acid substitution, which is associated with BMI in both sexes (P = 0.021 for women, P = 0.023 for men, and P = 0.0015 for joint analysis). These results support a role for CIDEA alleles in human obesity. CIDEA-deficient mice display higher metabolic rate, and the gene cross-talks with tumor necrosis factor-α (TNF-α) in fat cells. We hypothesize that CIDEA alleles regulate human obesity through impact on basal metabolic rate and adipocyte TNF-α signaling.
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