Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.

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Hou, Liping (author)

Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.

Article/chapterEnglish2016

Publisher, publication year, extent ...

2016-06-21
Oxford University Press (OUP),2016

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LIBRIS-ID:oai:gup.ub.gu.se/239372
https://gup.ub.gu.se/publication/239372URI
https://doi.org/10.1093/hmg/ddw181DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:135089540URI

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Language:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behavior. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ∼2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, p=5.87×10(-9); odds ratio=1.12) and markers within ERBB2 (rs2517959, p=4.53×10(-9); odds ratio=1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng

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Bergen, Sarah EKarolinska Institutet (author)
Akula, Nirmala (author)
Song, JieKarolinska Institutet (author)
Hultman, Christina MKarolinska Institutet (author)
Landén, Mikael,1966Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xlandt (author)
Adli, Mazda (author)
Alda, Martin (author)
Ardau, Raffaella (author)
Arias, Bárbara (author)
Aubry, Jean-Michel (author)
Backlund, LenaKarolinska Institutet (author)
Badner, Judith A (author)
Barrett, Thomas B (author)
Bauer, Michael (author)
Baune, Bernhard T (author)
Bellivier, Frank (author)
Benabarre, Antonio (author)
Bengesser, Susanne (author)
Berrettini, Wade H (author)
Bhattacharjee, Abesh Kumar (author)
Biernacka, Joanna M (author)
Birner, Armin (author)
Bloss, Cinnamon S (author)
Brichant-Petitjean, Clara (author)
Bui, Elise T (author)
Byerley, William (author)
Cervantes, Pablo (author)
Chillotti, CaterinaKarolinska Institutet (author)
Cichon, Sven (author)
Colom, Francesc (author)
Coryell, William (author)
Craig, David W (author)
Cruceanu, Cristiana (author)
Czerski, Piotr M (author)
Davis, Tony (author)
Dayer, Alexandre (author)
Degenhardt, Franziska (author)
Del Zompo, Maria (author)
DePaulo, J Raymond (author)
Edenberg, Howard J (author)
Étain, Bruno (author)
Falkai, Peter (author)
Foroud, Tatiana (author)
Forstner, Andreas J (author)
Frisén, LouiseKarolinska Institutet (author)
Frye, Mark A (author)
Fullerton, Janice M (author)
Gard, Sébastien (author)
Garnham, Julie S (author)
Gershon, Elliot S (author)
Goes, Fernando S (author)
Greenwood, Tiffany A (author)
Grigoroiu-Serbanescu, Maria (author)
Hauser, Joanna (author)
Heilbronner, Urs (author)
Heilmann-Heimbach, Stefanie (author)
Herms, Stefan (author)
Hipolito, Maria (author)
Hitturlingappa, Shashi (author)
Hoffmann, Per (author)
Hofmann, Andrea (author)
Jamain, Stephane (author)
Jiménez, Esther (author)
Kahn, Jean-Pierre (author)
Kassem, Layla (author)
Kelsoe, John R (author)
Kittel-Schneider, Sarah (author)
Kliwicki, Sebastian (author)
Koller, Daniel L (author)
König, Barbara (author)
Lackner, Nina (author)
Laje, Gonzalo (author)
Lang, Maren (author)
Lavebratt, Catharina (author)
Lawson, William B (author)
Leboyer, Marion (author)
Leckband, Susan G (author)
Liu, Chunyu (author)
Maaser, Anna (author)
Mahon, Pamela B (author)
Maier, Wolfgang (author)
Maj, MarioKarolinska Institutet (author)
Manchia, Mirko (author)
Martinsson, LinaKarolinska Institutet (author)
McCarthy, Michael J (author)
McElroy, Susan L (author)
McInnis, Melvin G (author)
McKinney, Rebecca (author)
Mitchell, Philip B (author)
Mitjans, Marina (author)
Mondimore, Francis M (author)
Monteleone, Palmiero (author)
Mühleisen, Thomas W (author)
Nievergelt, Caroline M (author)
Nöthen, Markus M (author)
Novák, Tomas (author)
Nurnberger, John I (author)
Nwulia, Evaristus A (author)
Ösby, Urban (author)
Pfennig, Andrea (author)
Potash, James B (author)
Propping, Peter (author)
Reif, Andreas (author)
Reininghaus, Eva (author)
Rice, John (author)
Rietschel, Marcella (author)
Rouleau, Guy A (author)
Rybakowski, Janusz K (author)
Schalling, Martin (author)
Scheftner, William A (author)
Schofield, Peter R (author)
Schork, Nicholas J (author)
Schulze, Thomas G (author)
Schumacher, Johannes (author)
Schweizer, Barbara W (author)
Severino, Giovanni (author)
Shekhtman, Tatyana (author)
Shilling, Paul D (author)
Simhandl, Christian (author)
Slaney, Claire M (author)
Smith, Erin N (author)
Squassina, Alessio (author)
Stamm, Thomas (author)
Stopkova, Pavla (author)
Streit, Fabian (author)
Strohmaier, Jana (author)
Szelinger, Szabolcs (author)
Tighe, Sarah K (author)
Tortorella, Alfonso (author)
Turecki, Gustavo (author)
Vieta, Eduard (author)
Volkert, Julia (author)
Witt, Stephanie H (author)
Wright, Adam (author)
Zandi, Peter P (author)
Zhang, Peng (author)
Zollner, Sebastian (author)
McMahon, Francis J (author)
Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi (creator_code:org_t)

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In:Human molecular genetics: Oxford University Press (OUP)25:15, s. 3383-941460-20830964-6906

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By the author/editor: Hou, Liping; Bergen, Sarah E; Akula, Nirmala; Song, Jie; Hultman, Christi ...; Landén, Mikael, ...; show more...; Adli, Mazda; Alda, Martin; Ardau, Raffaella; Arias, Bárbara; Aubry, Jean-Mich ...; Backlund, Lena; Badner, Judith A; Barrett, Thomas ...; Bauer, Michael; Baune, Bernhard ...; Bellivier, Frank; Benabarre, Anton ...; Bengesser, Susan ...; Berrettini, Wade ...; Bhattacharjee, A ...; Biernacka, Joann ...; Birner, Armin; Bloss, Cinnamon ...; Brichant-Petitje ...; Bui, Elise T; Byerley, William; Cervantes, Pablo; Chillotti, Cater ...; Cichon, Sven; Colom, Francesc; Coryell, William; Craig, David W; Cruceanu, Cristi ...; Czerski, Piotr M; Davis, Tony; Dayer, Alexandre; Degenhardt, Fran ...; Del Zompo, Maria; DePaulo, J Raymo ...; Edenberg, Howard ...; Étain, Bruno; Falkai, Peter; Foroud, Tatiana; Forstner, Andrea ...; Frisén, Louise; Frye, Mark A; Fullerton, Janic ...; Gard, Sébastien; Garnham, Julie S; Gershon, Elliot ...; Goes, Fernando S; Greenwood, Tiffa ...; Grigoroiu-Serban ...; Hauser, Joanna; Heilbronner, Urs; Heilmann-Heimbac ...; Herms, Stefan; Hipolito, Maria; Hitturlingappa, ...; Hoffmann, Per; Hofmann, Andrea; Jamain, Stephane; Jiménez, Esther; Kahn, Jean-Pierr ...; Kassem, Layla; Kelsoe, John R; Kittel-Schneider ...; Kliwicki, Sebast ...; Koller, Daniel L; König, Barbara; Lackner, Nina; Laje, Gonzalo; Lang, Maren; Lavebratt, Catha ...; Lawson, William ...; Leboyer, Marion; Leckband, Susan ...; Liu, Chunyu; Maaser, Anna; Mahon, Pamela B; Maier, Wolfgang; Maj, Mario; Manchia, Mirko; Martinsson, Lina; McCarthy, Michae ...; McElroy, Susan L; McInnis, Melvin ...; McKinney, Rebecc ...; Mitchell, Philip ...; Mitjans, Marina; Mondimore, Franc ...; Monteleone, Palm ...; Mühleisen, Thoma ...; Nievergelt, Caro ...; Nöthen, Markus M; Novák, Tomas; Nurnberger, John ...; Nwulia, Evaristu ...; Ösby, Urban; Pfennig, Andrea; Potash, James B; Propping, Peter; Reif, Andreas; Reininghaus, Eva; Rice, John; Rietschel, Marce ...; Rouleau, Guy A; Rybakowski, Janu ...; Schalling, Marti ...; Scheftner, Willi ...; Schofield, Peter ...; Schork, Nicholas ...; Schulze, Thomas ...; Schumacher, Joha ...; Schweizer, Barba ...; Severino, Giovan ...; Shekhtman, Tatya ...; Shilling, Paul D; Simhandl, Christ ...; Slaney, Claire M; Smith, Erin N; Squassina, Aless ...; Stamm, Thomas; Stopkova, Pavla; Streit, Fabian; Strohmaier, Jana; Szelinger, Szabo ...; Tighe, Sarah K; Tortorella, Alfo ...; Turecki, Gustavo; Vieta, Eduard; Volkert, Julia; Witt, Stephanie ...; Wright, Adam; Zandi, Peter P; Zhang, Peng; Zollner, Sebasti ...; McMahon, Francis ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

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By the university: University of Gothenburg; Karolinska Institutet

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