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Increased cell deat...
Increased cell death and delayed development in the cerebellum of mice lacking the rev-erbA(alpha) orphan receptor
- Article/chapterEnglish2000
Publisher, publication year, extent ...
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2000-04-01
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The Company of Biologists,2000
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:1942139
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1942139URI
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https://doi.org/10.1242/dev.127.7.1489DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The rev-erbAα gene, belonging to the steroid receptor superfamily of transcription factors, is highly conserved during evolution but little is known so far about its functions in development or in adult physiology. Here, we describe genetically altered mice lacking the rev-erbAα gene. These animals do not show any obvious phenotype in either fat tissue or skeletal muscle, despite the known regulation of rev-erbAα expression during adipocyte and myotube differentiation in vitro. However, during the second week of life, the cerebellum of rev-erbAα mutants presents several unexpected abnormalities, such as alterations in the development of Purkinje cells, delay in the proliferation and migration of granule cells from the external granule cell layer and increased apoptosis of neurons in the internal granule cell layer. Interestingly, the expression pattern of rev-erbAα suggests that the abnormalities observed in the external granule cell layer could be secondary to Purkinje cell alterations. Taken together, our data underline the importance of rev-erbAα expression for the appropriate balance of transcriptional activators and repressors during postnatal cerebellar development.
Added entries (persons, corporate bodies, meetings, titles ...)
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Neveu, I
(author)
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Mansen, A
(author)
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Kiesler, E
(author)
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Larsson, LKarolinska Institutet
(author)
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Vennstrom, BKarolinska Institutet
(author)
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Arenas, EKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Development (Cambridge, England): The Company of Biologists127:7, s. 1489-14980950-19911477-9129
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