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Modeling the mechan...
Modeling the mechanisms of biological GTP hydrolysis
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- Carvalho, Alexandra T. P. (author)
- Uppsala universitet,Institutionen för cell- och molekylärbiologi,Science for Life Laboratory, SciLifeLab
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- Szeler, Klaudia (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för cell- och molekylärbiologi
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- Vavitsas, Konstantinos (author)
- Univ Copenhagen, Dept Plant & Environm Sci, CPSC, DK-1871 Frederiksberg C, Denmark.
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- Åqvist, Johan (author)
- Uppsala universitet,Beräknings- och systembiologi,Science for Life Laboratory, SciLifeLab
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- Kamerlin, Lynn Shina C. (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Struktur- och molekylärbiologi
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: Archives of Biochemistry and Biophysics. - : Elsevier BV. - 0003-9861 .- 1096-0384. ; 582:SI, s. 80-90
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Abstract
Subject headings
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- Enzymes that hydrolyze GTP are currently in the spotlight, due to their molecular switch mechanism that controls many cellular processes. One of the best-known classes of these enzymes are small GTPases such as members of the Ras superfamily, which catalyze the hydrolysis of the gamma-phosphate bond in GTP. In addition, the availability of an increasing number of crystal structures of translational GTPases such as EF-Tu and EF-G have made it possible to probe the molecular details of GTP hydrolysis on the ribosome. However, despite a wealth of biochemical, structural and computational data, the way in which GTP hydrolysis is activated and regulated is still a controversial topic and well-designed simulations can play an important role in resolving and rationalizing the experimental data. In this review, we discuss the contributions of computational biology to our understanding of GTP hydrolysis on the ribosome and in small GTPases.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- GTP hydrolysis
- Ras GTPase
- EF-Tu
- EF-G
- Computational biology
Publication and Content Type
- ref (subject category)
- for (subject category)
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