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Distributions of lu...
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Rohdin, MKarolinska Institutet
(författare)
Distributions of lung ventilation and perfusion in prone and supine humans exposed to hypergravity
- Artikel/kapitelEngelska2004
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American Physiological Society,2004
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:1946789
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1946789URI
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https://doi.org/10.1152/japplphysiol.01259.2003DOI
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Språk:engelska
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Sammanfattning på:engelska
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When normal subjects are exposed to hypergravity [5 times normal gravity (5 G)] there is an impaired arterial oxygenation that is less severe in the prone compared with supine posture. We hypothesized that under these conditions the heterogeneities of ventilation and/or perfusion distributions would be less prominent when subjects were prone compared with supine. Expirograms from a combined rebreathing-single breath washout maneuver (Rohdin M, Sundblad P, and Linnarsson D. J Appl Physiol 96: 1470–1477, 2004) were analyzed for vital capacity (VC), phase III slope, and phase IV amplitude, to analyze heterogeneities in ventilation (Ar) and perfusion [CO2-to-Ar ratio (CO2/Ar)] distribution, respectively. During hypergravity, VC decreased more in the supine than in the prone position (ANOVA, P = 0.02). Phase III slope was more positive for Ar ( P = 0.003) and more negative for CO2/Ar ( P = 0.007) in the supine compared with prone posture at 5 G, in agreement with the notion of a more severe hypergravity-induced ventilation-perfusion mismatch in supine posture. Phase IV amplitude became lower in the supine than in the prone posture for both Ar ( P = 0.02) and CO2/Ar ( P = 0.004) during hypergravity as a result of the more reduced VC in the supine posture. We speculate that results of VC and phase IV amplitude are due to the differences in heart-lung interaction and diaphragm position between postures: a stable position of the heart and diaphragm in prone hypergravity, in contrast to supine in which the weight of the heart and a cephalad shift of the diaphragm compress lung tissue.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Petersson, JKarolinska Institutet
(författare)
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Mure, MKarolinska Institutet
(författare)
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Glenny, RW
(författare)
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Lindahl, SGEKarolinska Institutet
(författare)
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Linnarsson, DKarolinska Institutet
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of applied physiology (Bethesda, Md. : 1985): American Physiological Society97:2, s. 675-6828750-75871522-1601
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