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  • Bornehag, Carl-Gustaf,1957-Karlstads universitet,Institutionen för hälsovetenskaper (from 2013) (författare)

Prenatal Phthalate Exposures and Anogenital Distance in Swedish Boys

  • Artikel/kapitelEngelska2015

Förlag, utgivningsår, omfång ...

  • Environmental Health Perspectives,2015
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kau-41664
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-41664URI
  • https://doi.org/10.1289/ehp.1408163DOI
  • https://lup.lub.lu.se/record/5076058URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: Phthalates are used as plasticizers in soft polyvinyl chloride (PVC) and in a large number of consumer products. Because of reported health risks, diisononyl phthalate (DiNP) has been introduced as a replacement for di(2-ethylhexyl) phthalate (DEHP) in soft PVC. This raises concerns because animal data suggest that DiNP may have antiandrogenic properties similar to those of DEHP. The anogenital distance (AGD)-the distance from the anus to the genitals-has been used to assess reproductive toxicity. OBJECTIVE: The objective of this study was to examine the associations between prenatal phthalate exposure and AGD in Swedish infants. METHODS: AGD was measured in 196 boys at 21 months of age, and first-trimester urine was analyzed for 10 phthalate metabolites of DEP (diethyl phthalate), DBP (dibutyl phthalate), DEHP, BBzP (benzylbutyl phthalate), as well as DiNP and creatinine. Data on covariates were collected by questionnaires. RESULTS: The most significant associations were found between the shorter of two AGD measures (anoscrotal distance; AGDas) and DiNP metabolites and strongest for oh-MMeOP [mono(4-methyl-7-hydroxyloctyl) phthalate] and oxo-MMeOP [mono-(2-ethyl-5-oxohexyl) phthalate]. However, the AGDas reduction was small (4%) in relation to more than an interquartile range increase in DiNP exposure. CONCLUSIONS: These findings call into question the safety of substituting DiNP for DEHP in soft PVC, particularly because a shorter male AGD has been shown to relate to male genital birth defects in children and impaired reproductive function in adult males and the fact that human levels of DiNP are increasing globally.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Carlstedt, FredrikCty Council Varmland, Karlstad, Sweden. (författare)
  • Jönsson, Bo ALund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Div Occupat & Environm Med, Lund, Sweden.(Swepub:lu)ymed-bjo (författare)
  • Lindh, ChristianLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Div Occupat & Environm Med, Lund, Sweden.(Swepub:lu)ymed-cli (författare)
  • Jensen, Tina K.Univ Southern Denmark, Dept Environm Med, Odense, Denmark. (författare)
  • Bodin, AnnaCty Council Varmland, Karlstad, Sweden. (författare)
  • Jonsson, CarinCty Council Varmland, Karlstad, Sweden. (författare)
  • Janson, Staffan,1945-Karlstads universitet,Institutionen för hälsovetenskaper (from 2013)(Swepub:kau)stafjans (författare)
  • Swan, Shanna H.Icahn Sch Med Mt Sinai, New York, NY 10029 USA. (författare)
  • Karlstads universitetInstitutionen för hälsovetenskaper (from 2013) (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Environmental Health Perspectives: Environmental Health Perspectives123:1, s. 101-1070091-67651552-9924

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