Sökning: L773:1479 683X OR L773:0804 4643
> (2000-2004) >
Circulating insulin...
-
Oskarsson, PR
(författare)
Circulating insulin inhibits glucagon secretion induced by arginine in type 1 diabetes
- Artikel/kapitelEngelska2000
Förlag, utgivningsår, omfång ...
-
Oxford University Press (OUP),2000
Nummerbeteckningar
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:1954903
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:1954903URI
-
https://doi.org/10.1530/eje.0.1420030DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
OBJECTIVE: To evaluate if insulin has a suppressive effect on the glucagon secretion stimulated by arginine in type 1 diabetes. RESEARCH DESIGN AND METHODS: The alpha-cell response to an i.v. bolus of arginine (150mgkg(-1)) followed by an infusion of arginine (10mgkg(-1)min(-1)) was studied in random order during either low dose infusion (LDT) or high dose infusion (HDT) of insulin in ten patients with type 1 diabetes. The blood glucose level was clamped at an arterialized level of 5mmoll(-1) by a variable infusion of glucose. Venous C-peptide, glucagon, growth hormone, and insulin were analyzed. RESULTS: The mean plasma concentration of insulin was four times higher during the HDT. The C-peptide level did not differ between the LDT and the HDT. During the LDT in response to arginine the blood glucose level increased from 5.0 to 5.8mmol l(-1) although the glucose infusion was markedly reduced, while no change was seen during the HDT. A significantly smaller increase in the glucagon levels during the HDT was seen (area under the curve of 413+/-45 vs 466+/-44pgml(-1)h(-1), P=0.03) while the growth hormone levels were almost identical. CONCLUSION: This study demonstrates that a high level of circulating insulin exerts an inhibitory effect on the glucagon response to arginine in type 1 diabetes. Thus, the suppressive effect of insulin on the glucagon release from the alpha-cell seems to be general and not only dependent on stimulation by hypoglycemia.
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Lins, PEKarolinska Institutet
(författare)
-
Ahren, B
(författare)
-
Adamson, UC
(författare)
-
Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:European journal of endocrinology: Oxford University Press (OUP)142:1, s. 30-340804-46431479-683X
Internetlänk
Hitta via bibliotek
Till lärosätets databas