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Amelotin--a Novel S...
Amelotin--a Novel Secreted, Ameloblast-specific Protein
- Artikel/kapitelEngelska2005
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2016-12-15
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SAGE Publications,2005
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:1956247
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1956247URI
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https://doi.org/10.1177/154405910508401207DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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We aimed to analyze the differential gene expression in various murine dental tissues, expecting to find novel factors that are involved in tooth formation. We here describe the identification of a novel ameloblast-specific gene, amelotin (AMTN), by differential display polymerase chain-reaction (DD-PCR) analysis of microdissected ameloblasts, odontoblasts, dental pulp, and alveolar bone cells of 10-day-old mouse incisors. The conceptually translated protein sequence was unique and showed significant homology only with its human orthologue. The amelotin genes from mouse and human displayed a similar exon-intron structure and were expressed from loci on chromosomes 5 and 4, respectively, which have been associated with various forms of amelogenesis imperfecta. Expression of amelotin mRNA was restricted to maturation-stage ameloblasts in developing murine molars and incisors. Amelotin protein was efficiently secreted from transfected cells in culture. Taken together, our findings suggest that amelotin is a novel factor produced by ameloblasts that plays a critical role in the formation of dental enamel.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Bajenova, E
(författare)
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Somogyi-Ganss, E
(författare)
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Miller, M
(författare)
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Nguyen, V
(författare)
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Nourkeyhani, H
(författare)
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Gao, Y
(författare)
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Wendel, M
(författare)
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Ganss, B
(författare)
Sammanhörande titlar
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Ingår i:Journal of dental research: SAGE Publications84:12, s. 1127-11320022-03451544-0591
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