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Recruitment of pre-...
Recruitment of pre-dementia participants: main enrollment barriers in a longitudinal amyloid-PET study
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- Bader, I. (författare)
- Vrije Universiteit Amsterdam,Amsterdam Neuroscience
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Bader, I. (författare)
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- Alves, I. L. (författare)
- Amsterdam Neuroscience,Vrije Universiteit Amsterdam
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- García, D. V. (författare)
- Vrije Universiteit Amsterdam,Amsterdam Neuroscience
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- Vellas, B. (författare)
- Toulouse University Hospital
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- Dubois, B. (författare)
- Pitié-Salpêtrière University Hospital
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- Boada, M. (författare)
- CIBER Enfermedades Neurodegenerativas (CIBERNED),International University of Catalonia
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- Marquié, M. (författare)
- Karolinska Institutet,CIBER Enfermedades Neurodegenerativas (CIBERNED),International University of Catalonia
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- Altomare, D. (författare)
- University of Brescia
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- Scheltens, P. (författare)
- Amsterdam Neuroscience,Vrije Universiteit Amsterdam
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Vandenberghe, R. (författare)
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- Hanseeuw, B. (författare)
- Saint-Luc University Hospital,Catholic University of Louvain,Massachusetts General Hospital
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- Schöll, Michael, 1980 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Wallenberg Centre for Molecular and Translational Medicine,Institute of Neuroscience and Physiology,Sahlgrenska Academy,University College London
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- Frisoni, G. B. (författare)
- Geneva University Hospital,University of Geneva
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- Jessen, F. (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Nordberg, A. (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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- Kivipelto, M. (författare)
- Karolinska Institute,Imperial College London,Kuopio University Hospital
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- Ritchie, C. W. (författare)
- University of Edinburgh
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- Grau-Rivera, O. (författare)
- Pasqual Maragall Foundation for Research on Alzheimer
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- Molinuevo, J. L. (författare)
- H. Lundbeck A/S,Pasqual Maragall Foundation for Research on Alzheimer
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- Ford, L. (författare)
- Janssen Research & Development, Belgium
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Stephens, A. (författare)
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Gismondi, R. (författare)
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- Gispert, J. D. (författare)
- Pasqual Maragall Foundation for Research on Alzheimer
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- Farrar, G. (författare)
- GE Healthcare, UK
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- Barkhof, F. (författare)
- Amsterdam Neuroscience,Vrije Universiteit Amsterdam,University College London
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- Visser, P. J. (författare)
- Vrije Universiteit Amsterdam,Maastricht University,Amsterdam Neuroscience
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- Collij, Lyduine E. (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Vrije Universiteit Amsterdam,Amsterdam Neuroscience
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Amypad Consortium, Amypad Consortium (författare)
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Alzheimer's Research & Therapy. - 1758-9193. ; 15:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background The mismatch between the limited availability versus the high demand of participants who are in the pre-dementia phase of Alzheimer's disease (AD) is a bottleneck for clinical studies in AD. Nevertheless, potential enrollment barriers in the pre-dementia population are relatively under-reported. In a large European longitudinal biomarker study (the AMYPAD-PNHS), we investigated main enrollment barriers in individuals with no or mild symptoms recruited from research and clinical parent cohorts (PCs) of ongoing observational studies.Methods Logistic regression was used to predict study refusal based on sex, age, education, global cognition (MMSE), family history of dementia, and number of prior study visits. Study refusal rates and categorized enrollment barriers were compared between PCs using chi-squared tests.Results 535/1856 (28.8%) of the participants recruited from ongoing studies declined participation in the AMYPAD-PNHS. Only for participants recruited from clinical PCs (n = 243), a higher MMSE-score (beta = - 0.22, OR = 0.80, p < .05), more prior study visits (beta = - 0.93, OR = 0.40, p < .001), and positive family history of dementia (beta = 2.08, OR = 8.02, p < .01) resulted in lower odds on study refusal. General study burden was the main enrollment barrier (36.1%), followed by amyloid-PET related burden (PCresearch = 27.4%, PCclinical = 9.0%, X-2 = 10.56, p = .001), and loss of research interest (PCclinical = 46.3%, PCresearch = 16.5%, X-2 = 32.34, p < .001).Conclusions The enrollment rate for the AMYPAD-PNHS was relatively high, suggesting an advantage of recruitment via ongoing studies. In this observational cohort, study burden reduction and tailored strategies may potentially improve participant enrollment into trial readiness cohorts such as for phase-3 early anti-amyloid intervention trials. The AMYPAD-PNHS (EudraCT: 2018-002277-22) was approved by the ethical review board of the VU Medical Center (VUmc) as the Sponsor site and in every affiliated site.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer's disease
- Preclinical
- Recruitment
- Enrollment barriers
- Amyloid PET
- Clinical trial
- alzheimers-disease
- clinical-trials
- retention
- strategies
- disclosure
- framework
- patient
- memory
- Neurosciences & Neurology
- Alzheimer’s disease
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Bader, I.
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Alves, I. L.
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García, D. V.
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Vellas, B.
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Dubois, B.
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visa fler...
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Boada, M.
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Marquié, M.
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Altomare, D.
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Scheltens, P.
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Vandenberghe, R.
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Hanseeuw, B.
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Schöll, Michael, ...
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Frisoni, G. B.
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Jessen, F.
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Nordberg, A.
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Kivipelto, M.
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Ritchie, C. W.
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Grau-Rivera, O.
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Molinuevo, J. L.
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Ford, L.
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Stephens, A.
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Gismondi, R.
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Gispert, J. D.
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Farrar, G.
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Barkhof, F.
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Visser, P. J.
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Collij, Lyduine ...
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Amypad Consortiu ...
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och Neurovetenskaper
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Göteborgs universitet
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Karolinska Institutet
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Lunds universitet