TNF-alpha: a link between hypertriglyceridaemia and inflammation in SLE patients with cardiovascular disease

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Svenungsson, EKarolinska Institutet (author)

TNF-alpha: a link between hypertriglyceridaemia and inflammation in SLE patients with cardiovascular disease

Article/chapterEnglish2003

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2016-07-02
SAGE Publications,2003

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LIBRIS-ID:oai:prod.swepub.kib.ki.se:1960610
http://kipublications.ki.se/Default.aspx?queryparsed=id:1960610URI
https://doi.org/10.1191/0961203303lu412oaDOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Patients with systemic lupus erythematosus (SLE) are at high risk of cardiovascular disease (CVD). Tumour necrosisfactor-a (TNF-α) has been implicatedin the pathophysiologicalprocessesof both SLE and CVD. This study focuses on the role of TNF-α and its soluble receptors in SLE-related CVD. In summary, 26 women (52 + 8.2 years) with SLE and a history of CVD (SLE cases)were compared with 26 age-matched women with SLE and no clinical manifestations of CVD (SLE controls) and 26 age-matched population-based control women (population controls). Plasma concentrations of circulating TNF-α, TNF-α receptor 1 (sTNFR1) and TNF-α receptor 2 (sTNFR2) were determined by ELISA. TNF-α, sTNFR1 and sTNFR2 were raised in SLE cases as compared to SLE controls ( P = 0.009; P = 0.001; P = 0.001, respectively), and SLE controls had higher levels than population controls ( P = 0.001; P = 0.02; P = 0.001, respectively). Exclusively in the SLE case group there was a striking positivecorrelationbetweenTNF-α and plasma triglycerides( r = 0.57, P < 0.002), VLDL triglycerides ( r = 0.54, P = 0.004) and VLDL cholesterol ( r = 0.58, P = 0.002). Furthermore, TNF-α correlated with the waist-hip ratio but not with estimated insulin resistance. TNF-α may thus be a major factor in SLE-related CVD acting both by contributing to hypertriglyceridaemia and by promoting atherosclerosis-relatedinflammation. sTNFR1 and sTNFR2 are strongly associated with CVD in SLE but their exact roles in disease development remain to be elucidated.

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Fei, GZ (author)
Jensen-Urstad, KKarolinska Institutet (author)
de Faire, UKarolinska Institutet (author)
Hamsten, AKarolinska Institutet (author)
Frostegard, JKarolinska Institutet (author)
Karolinska Institutet (creator_code:org_t)

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In:Lupus: SAGE Publications12:6, s. 454-4610961-20331477-0962

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By the author/editor: Svenungsson, E; Fei, GZ; Jensen-Urstad, K; de Faire, U; Hamsten, A; Frostegard, J

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