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Myeloid and plasmac...
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Lore, KKarolinska Institutet
(författare)
Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4+ T cells
- Artikel/kapitelEngelska2005
Förlag, utgivningsår, omfång ...
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2005-06-20
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Rockefeller University Press,2005
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:1961565
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1961565URI
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https://doi.org/10.1084/jem.20042413DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Dendritic cells (DCs) are essential antigen-presenting cells for the induction of T cell immunity against pathogens such as human immunodeficiency virus (HIV)-1. At the same time, HIV-1 replication is strongly enhanced in DC–T cell clusters, potentially undermining this process. We found that immature CD123+ plasmacytoid DCs (PDCs) and CD11c+ myeloid DCs (MDCs) were susceptible to both a CCR5- and a CXCR4-using HIV-1 isolate in vitro and were able to efficiently transfer that infection to autologous CD4+ T cells. Soon after HIV-1 exposure, both PDCs and MDCs were able to transfer the virus to T cells in the absence of a productive infection. However, once a productive infection was established in the DCs, newly synthesized virus was predominantly spread to T cells. HIV-1 exposure of the MDCs and PDCs did not inhibit their ability to present cytomegalovirus (CMV) antigens and activate CMV-specific memory T cells. As a result, both PDCs and MDCs preferentially transmitted HIV-1 to the responding CMV antigen–specific CD4+ T cells rather than to nonresponding T cells. This suggests that the induction of antigen-specific T cell responses by DCs, a process crucial to immune defense, can lead to preferential HIV-1 infection and the deletion of responding CD4+ T cells.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Smed-Sorensen, AKarolinska Institutet
(författare)
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Vasudevan, J
(författare)
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Mascola, JR
(författare)
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Koup, RA
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:The Journal of experimental medicine: Rockefeller University Press201:12, s. 2023-20330022-10071540-9538
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