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Unrecognized myocar...
Unrecognized myocardial infarctions detected by cardiac magnetic resonance imaging are associated with cardiac troponin I levels
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- Nordenskjöld, Anna M., 1977- (författare)
- Univ Orebro, Fac Hlth, Dept Cardiol, S-70185 Orebro, Sweden.,Department of Cardiology, Faculty of Health, Örebro University, Örebro, Sweden
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- Hammar, Per (författare)
- Uppsala universitet,Radiologi,Vasteras Hosp, Dept Radiol, Vasteras, Sweden.,Department of Radiology, Västerås Hospital, Västerås, Sweden; Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden
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- Ahlström, Håkan (författare)
- Uppsala universitet,Radiologi,Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden
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- Bjerner, Tomas (författare)
- Uppsala universitet,Radiologi,Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden
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- Duvernoy, Olov (författare)
- Uppsala universitet,Radiologi,Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden
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- Eggers, Kai M. (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Centre, Uppsala, Sweden
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- Fröbert, Ole, 1964- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology
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- Hadziosmanovic, Nermin (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Uppsala Clinical Research Centre, Uppsala, Sweden
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- Lindahl, Bertil (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Centre, Uppsala, Sweden
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Univ Orebro, Fac Hlth, Dept Cardiol, S-70185 Orebro, Sweden Department of Cardiology, Faculty of Health, Örebro University, Örebro, Sweden (creator_code:org_t)
- Amsterdam, Netherlands : Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: Clinica Chimica Acta. - Amsterdam, Netherlands : Elsevier BV. - 0009-8981 .- 1873-3492. ; 455, s. 189-194
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Both unrecognized myocardial infarction (UMI) and elevated levels of biomarkers are common in patients with stable coronary artery disease (CAD). The objective of this study was to determine the association between levels of cardiac biomarkers, UMI and extent of CAD in patients with stable CAD.Methods: A total of 235 patients (median age: 65 years; 34% women) with stable CAD without previously known myocardial infarction were examined with late gadolinium enhancement cardiovascular magnetic resonance imaging and coronary angiography. Blood samples were drawn at enrolment and high sensitivity cardiac troponin I (cTnI), NT-proBNP and Galectin-3 were analyzed.Results: UMI was detected in 58 patients (25%). The median levels of cTnI, NT-proBNP and Galectin-3 were significantly higher in patients with UMI compared to those without, (p < 0.001, p = 0.006 and p = 0.033, respectively). After adjustment for cardiovascular risk factors, left ventricular ejection fraction and renal function, cTnI remained independently associated with the presence of UMI (p = 0.031) and the extent of CAD (p = 0.047). Neither NT-proBNP, nor Galectin-3, was independently associated with UMI or extent of CAD.Conclusions: The independent association between levels of cTnI and UMI indicates a common pathophysiological pathway for the cTnI elevation and development of UMI.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Cardiac troponin
- NT-proBNP
- Unrecognized myocardial infarction
- Coronary artery disease
- Cardiac magnetic resonance imaging
- Cardiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Nordenskjöld, An ...
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Hammar, Per
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Ahlström, Håkan
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Bjerner, Tomas
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Duvernoy, Olov
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Eggers, Kai M.
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Fröbert, Ole, 19 ...
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Hadziosmanovic, ...
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Lindahl, Bertil
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Clinica Chimica ...
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