Search: (WFRF:(Frykman V))
> (2020-2023) >
Clinical and echoca...
Clinical and echocardiographic characteristics of individuals aged 75/76 years old with screening-detected elevated NT-proBNP levels
-
- Al-Khalili, F (author)
- Karolinska Institutet
-
- Kemp-Gudmundsdottir, K (author)
- Karolinska Institutet
-
- Svennberg, E (author)
- Karolinska Institutet
-
show more...
-
- Fredriksson, T (author)
- Karolinska Institutet
-
- Frykman, V (author)
- Karolinska Institutet
-
Friberg, L (author)
-
Rosenqvist, M (author)
-
- Engdahl, J (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- 2020-02-19
- 2020
- English.
-
In: Open heart. - : BMJ. - 2053-3624. ; 7:1, s. e001200-
- Related links:
-
https://openheart.bm...
-
show more...
-
http://kipublication...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- High plasma levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) indicate increased probability of congestive heart failure (CHF) and atrial fibrillation (AF) and are associated with poor prognosis.ObjectiveWe aimed to describe the clinical and echocardiographic characteristics of a population of individuals aged 75/76 years old with NT-proBNP ≥900 ng/L without previously known CHF or AF.MethodsAll individuals aged 75/76 years in the Stockholm region were randomised to a screening study for AF. Half of them were invited to screening. Of those invited, 49.5% agreed to participate. Individuals with NT-proBNP ≥900 ng/L without known CHF were invited for further clinical evaluation.ResultsAmong 6315 participants without AF who had NT-proBNP sampled, 102 without previously known CHF had ≥900 ng/L. Of these, 93 completed further clinical investigations. In the population that was clinically investigated, 53% were female, and the median NT-proBNP was 1200 ng/L. New AF was found in 28 (30%). The NT-proBNP value in this group was not significantly different from those where AF was not detected (median 1285 vs 1178 ng/L). Patients with newly detected AF had larger left atrial volume and higher pulmonary artery pressure than those without AF. Preserved left ventricular ejection fraction (≥50%) was found in 86% of the participants, mid-range ejection fraction (40%–49%) in 3.2% and reduced ejection fraction (<40%) in 10.8%. Thirteen patients (14%) had other serious cardiac disorders that required medical attention.ConclusionElderly individuals with NT-proBNP levels ≥900 ng/L constitute a population at high cardiovascular risk even in the absence of diagnosed CHF or AF, and therefore merit further investigation.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Open heart
(Search for host publication in LIBRIS)
To the university's database