Search: WFRF:(Gudmundsdottir E.) >
Clinical and echoca...
Clinical and echocardiographic characteristics of individuals aged 75/76 years old with screening-detected elevated NT-proBNP levels
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- Al-Khalili, F (author)
- Karolinska Institutet
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- Kemp-Gudmundsdottir, K (author)
- Karolinska Institutet
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- Svennberg, E (author)
- Karolinska Institutet
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- Fredriksson, T (author)
- Karolinska Institutet
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- Frykman, V (author)
- Karolinska Institutet
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Friberg, L (author)
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Rosenqvist, M (author)
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- Engdahl, J (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-02-19
- 2020
- English.
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In: Open heart. - : BMJ. - 2053-3624. ; 7:1, s. e001200-
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https://doi.org/10.1...
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Abstract
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- High plasma levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) indicate increased probability of congestive heart failure (CHF) and atrial fibrillation (AF) and are associated with poor prognosis.ObjectiveWe aimed to describe the clinical and echocardiographic characteristics of a population of individuals aged 75/76 years old with NT-proBNP ≥900 ng/L without previously known CHF or AF.MethodsAll individuals aged 75/76 years in the Stockholm region were randomised to a screening study for AF. Half of them were invited to screening. Of those invited, 49.5% agreed to participate. Individuals with NT-proBNP ≥900 ng/L without known CHF were invited for further clinical evaluation.ResultsAmong 6315 participants without AF who had NT-proBNP sampled, 102 without previously known CHF had ≥900 ng/L. Of these, 93 completed further clinical investigations. In the population that was clinically investigated, 53% were female, and the median NT-proBNP was 1200 ng/L. New AF was found in 28 (30%). The NT-proBNP value in this group was not significantly different from those where AF was not detected (median 1285 vs 1178 ng/L). Patients with newly detected AF had larger left atrial volume and higher pulmonary artery pressure than those without AF. Preserved left ventricular ejection fraction (≥50%) was found in 86% of the participants, mid-range ejection fraction (40%–49%) in 3.2% and reduced ejection fraction (<40%) in 10.8%. Thirteen patients (14%) had other serious cardiac disorders that required medical attention.ConclusionElderly individuals with NT-proBNP levels ≥900 ng/L constitute a population at high cardiovascular risk even in the absence of diagnosed CHF or AF, and therefore merit further investigation.
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