WFRF:(Peloso GM)
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- Huffman, J (author)
Alternative splicing of OAS1 alters the risk for severe COVID-19
- Article/chapterEnglish2021
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- Cold Spring Harbor Laboratory,2021
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- LIBRIS-ID:oai:prod.swepub.kib.ki.se:233791713
- http://kipublications.ki.se/Default.aspx?queryparsed=id:233791713URI
- https://doi.org/10.1101/2021.03.20.21254005DOI
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- Language:English
- Summary in:English
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- A locus containing OAS1/2/3 has been identified as a risk locus for severe COVID-19 among Europeans ancestry individuals, with a protective haplotype of ∼75 kilobases derived from Neanderthals. Here, we show that among several potentially causal variants at this locus, a splice variant of OAS1 occurs in people of African ancestry independently of the Neanderthal haplotype and confers protection against COVID-19 of a magnitude similar to that seen in individuals without African ancestry.
Added entries (persons, corporate bodies, meetings, titles ...)
- Butler-Laporte, G (author)
- Khan, A (author)
- Drivas, TG (author)
- Peloso, GM (author)
- Nakanishi, T (author)
- Verma, A (author)
- Kiryluk, K (author)
- Richards, JB (author)
- Zeberg, HKarolinska Institutet (author)
- Karolinska Institutet (creator_code:org_t)
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- In:medRxiv : the preprint server for health sciences: Cold Spring Harbor Laboratory
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