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  • Moridi, TKarolinska Institutet (author)

Association between brain volume and disability over time in multiple sclerosis

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-12-18
  • SAGE Publications,2022

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:236570871
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:236570871URI
  • https://doi.org/10.1177/20552173221144230DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Most previous multiple sclerosis (MS) brain atrophy studies using MS impact scale 29 (MSIS-29) or symbol digit modalities test (SDMT) have been cross-sectional with limited sets of clinical outcomes. Objectives To investigate which brain and lesion volume metrics show the strongest long-term associations with the expanded disability status scale (EDSS), SDMT, and MSIS-29, and whether MRI-clinical associations vary with age. Methods We acquired MRI and clinical data from a real-world Swedish MS cohort. FreeSurfer and SPM Lesion Segmentation Tool were used to obtain brain parenchymal, cortical and subcortical grey matter, thalamic and white matter fractions as well as T1- and T2-lesion volumes. Mixed-effects and rolling regression models were used in the statistical analyses. Results We included 989 persons with MS followed for a median of 9.3 (EDSS), 10.1 (SDMT), and 9.3 (MSIS-29) years, respectively. In a cross-sectional analysis, the strength of the associations of the MRI metrics with the EDSS and MSIS-29 was found to drastically increase after 40–50 years of age. Low baseline regional grey matter fractions were associated with longitudinal increase of EDSS and physical MSIS-29 scores and decrease in SDMT scores and these atrophy measures were stronger predictors than the lesion volumes. Conclusions The strength of MRI-clinical associations increase with age. Grey matter volume fractions are stronger predictors of long-term disability measures than lesion volumes.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Stawiarz, LKarolinska Institutet (author)
  • McKay, KAKarolinska Institutet (author)
  • Ineichen, BV (author)
  • Ouellette, RKarolinska Institutet (author)
  • Ferreira, DKarolinska Institutet (author)
  • Muehlboeck, JSKarolinska Institutet (author)
  • Westman, EKarolinska Institutet (author)
  • Kockum, IKarolinska Institutet (author)
  • Olsson, TKarolinska Institutet (author)
  • Piehl, F (author)
  • Hillert, JKarolinska Institutet (author)
  • Manouchehrinia, AKarolinska Institutet (author)
  • Granberg, TKarolinska Institutet (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Multiple sclerosis journal - experimental, translational and clinical: SAGE Publications8:4, s. 20552173221144230-2055-2173

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