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The chromatin facto...
The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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Cold Spring Harbor Laboratory,2023
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:236993207
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http://kipublications.ki.se/Default.aspx?queryparsed=id:236993207URI
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https://doi.org/10.1101/2023.03.20.531974DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:vet swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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SET-26, HCF-1, and HDA-1 are highly conserved chromatin factors with key roles in development and aging. Here we present mechanistic insights into how these factors regulate gene expression and modulate longevity inC. elegans. We show that SET-26 and HCF-1 cooperate to regulate a common set of genes, and both antagonize the histone deacetylase HDA-1 to limit longevity. We propose a model in which SET-26 recruits HCF-1 to chromatin in somatic cells, where they stabilize each other at the promoters of a subset of genes, particularly mitochondrial function genes, and regulate their expression. HDA-1 opposes SET-26 and HCF-1 on the regulation of a subset of their common target genes and in longevity. Our findings suggest that SET-26, HCF-1, and HDA-1 comprise a mechanism to fine-tune gene expression and longevity and likely have important implications for the mechanistic understanding of how these factors function in diverse organisms, particularly in aging biology.
Added entries (persons, corporate bodies, meetings, titles ...)
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Chiu, C
(author)
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Lin, LY
(author)
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Riedel, CGKarolinska Institutet
(author)
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Zhu, M
(author)
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Lee, SS
(author)
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Karolinska Institutet
(creator_code:org_t)
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In:bioRxiv : the preprint server for biology: Cold Spring Harbor Laboratory
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