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Immunoglobulin G N-...
Immunoglobulin G N-Glycosylation Signatures in Incident Type 2 Diabetes and Cardiovascular Disease
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- Birukov, Anna (author)
- Harvard School of Public Health, United States
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Plavćsa, Branimir (author)
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Eichelmann, Fabian (author)
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Kuxhaus, Olga (author)
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- Hoshi, Rosangela Akemi (author)
- Harvard Medical School
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Rudman, Najda (author)
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Stambuk, Tamara (author)
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Trbojevićc-Akmaćcićc, Irena (author)
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Schiborn, Catarina (author)
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- Morze, Jakub (author)
- Harvard School of Public Health, United States,University of Warmia and Mazury in Olsztyn
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Mihelćcićc, Matea (author)
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Cindrićc, Ana (author)
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- Liu, Yanyan (author)
- Harvard Medical School
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- Demler, Olga (author)
- Harvard Medical School,Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH)
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- Perola, Markus (author)
- Helsingin Yliopisto,University of Helsinki
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- Mora, Samia (author)
- Harvard Medical School
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- Schulze, Matthias B. (author)
- Universität Potsdam,University of Potsdam
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Lauc, Gordan (author)
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- Wittenbecher, Clemens, 1981 (author)
- Harvard School of Public Health, United States,Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2022-10-25
- 2022
- English.
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In: Diabetes Care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 45:11, s. 2729-2736
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https://research.cha...
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https://doi.org/10.2...
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Abstract
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- OBJECTIVE N-glycosylation is a functional posttranslational modification of immunoglobulins (Igs). We hypothesized that specific IgG N-glycans are associated with incident type 2 diabetes and cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS We performed case-cohort studies within the population-based European Prospective Investigation into Cancer and Nutrition (EPIC)–Potsdam cohort (2,127 in the type 2 diabetes subcohort [741 incident cases]; 2,175 in the CVD subcohort [417 myocardial infarction and stroke cases]). Relative abundances of 24 IgG N-glycan peaks (IgG-GPs) were measured by ultraperformance liquid chromatog-raphy, and eight glycosylation traits were derived based on structural similarity. End point–associated IgG-GPs were preselected with fractional polynomials, and prospective associations were estimated in confounder-adjusted Cox models. Diabetes risk associations were validated in three independent studies. RESULTS After adjustment for confounders and multiple testing correction, IgG-GP7, IgG-GP8, IgG-GP9, IgG-GP11, and IgG-GP19 were associated with type 2 diabetes risk. A score based on these IgG-GPs was associated with a higher diabetes risk in EPIC-Potsdam and independent validation studies (843 total cases, 3,149 total non-cases, pooled estimate per SD increase 1.50 [95% CI 1.37–1.64]). Associations of IgG-GPs with CVD risk differed between men and women. In women, IgG-GP9 was inversely associated with CVD risk (hazard ratio [HR] per SD 0.80 [95% CI 0.65–0.98]). In men, a weighted score based on IgG-GP19 and IgG-GP23 was associated with higher CVD risk (HR per SD 1.47 [95% CI 1.20–1.80]). In addition, several derived traits were associated with cardiometabolic disease incidence. CONCLUSIONS Selected IgG N-glycans are associated with cardiometabolic risk beyond classic risk factors, including clinical biomarkers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Birukov, Anna
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Plavćsa, Branimi ...
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Eichelmann, Fabi ...
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Kuxhaus, Olga
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Hoshi, Rosangela ...
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Rudman, Najda
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show more...
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Stambuk, Tamara
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Trbojevićc-Akmać ...
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Schiborn, Catari ...
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Morze, Jakub
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Mihelćcićc, Mate ...
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Cindrićc, Ana
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Liu, Yanyan
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Demler, Olga
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Perola, Markus
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Mora, Samia
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Schulze, Matthia ...
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Lauc, Gordan
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Wittenbecher, Cl ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and General Practice
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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Diabetes Care
- By the university
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Chalmers University of Technology