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Immunoglobulin G N-...
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Birukov, AnnaHarvard School of Public Health, United States
(author)
Immunoglobulin G N-Glycosylation Signatures in Incident Type 2 Diabetes and Cardiovascular Disease
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-10-25
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American Diabetes Association,2022
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electronicrdacarrier
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LIBRIS-ID:oai:research.chalmers.se:004d517b-5e31-4f75-bc18-831bc02c56b0
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https://research.chalmers.se/publication/533138URI
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https://doi.org/10.2337/dc22-0833DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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OBJECTIVE N-glycosylation is a functional posttranslational modification of immunoglobulins (Igs). We hypothesized that specific IgG N-glycans are associated with incident type 2 diabetes and cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS We performed case-cohort studies within the population-based European Prospective Investigation into Cancer and Nutrition (EPIC)–Potsdam cohort (2,127 in the type 2 diabetes subcohort [741 incident cases]; 2,175 in the CVD subcohort [417 myocardial infarction and stroke cases]). Relative abundances of 24 IgG N-glycan peaks (IgG-GPs) were measured by ultraperformance liquid chromatog-raphy, and eight glycosylation traits were derived based on structural similarity. End point–associated IgG-GPs were preselected with fractional polynomials, and prospective associations were estimated in confounder-adjusted Cox models. Diabetes risk associations were validated in three independent studies. RESULTS After adjustment for confounders and multiple testing correction, IgG-GP7, IgG-GP8, IgG-GP9, IgG-GP11, and IgG-GP19 were associated with type 2 diabetes risk. A score based on these IgG-GPs was associated with a higher diabetes risk in EPIC-Potsdam and independent validation studies (843 total cases, 3,149 total non-cases, pooled estimate per SD increase 1.50 [95% CI 1.37–1.64]). Associations of IgG-GPs with CVD risk differed between men and women. In women, IgG-GP9 was inversely associated with CVD risk (hazard ratio [HR] per SD 0.80 [95% CI 0.65–0.98]). In men, a weighted score based on IgG-GP19 and IgG-GP23 was associated with higher CVD risk (HR per SD 1.47 [95% CI 1.20–1.80]). In addition, several derived traits were associated with cardiometabolic disease incidence. CONCLUSIONS Selected IgG N-glycans are associated with cardiometabolic risk beyond classic risk factors, including clinical biomarkers.
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Plavćsa, Branimir
(author)
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Eichelmann, Fabian
(author)
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Kuxhaus, Olga
(author)
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Hoshi, Rosangela AkemiHarvard Medical School
(author)
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Rudman, Najda
(author)
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Stambuk, Tamara
(author)
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Trbojevićc-Akmaćcićc, Irena
(author)
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Schiborn, Catarina
(author)
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Morze, JakubHarvard School of Public Health, United States,University of Warmia and Mazury in Olsztyn
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Mihelćcićc, Matea
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Cindrićc, Ana
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Liu, YanyanHarvard Medical School
(author)
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Demler, OlgaHarvard Medical School,Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH)
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Perola, MarkusHelsingin Yliopisto,University of Helsinki
(author)
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Mora, SamiaHarvard Medical School
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Schulze, Matthias B.Universität Potsdam,University of Potsdam
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Lauc, Gordan
(author)
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Wittenbecher, Clemens,1981Harvard School of Public Health, United States,Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)clemensw
(author)
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Harvard School of Public Health, United StatesHarvard Medical School
(creator_code:org_t)
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In:Diabetes Care: American Diabetes Association45:11, s. 2729-27361935-55480149-5992
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Birukov, Anna
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Plavćsa, Branimi ...
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Eichelmann, Fabi ...
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Kuxhaus, Olga
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Hoshi, Rosangela ...
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Rudman, Najda
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Stambuk, Tamara
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Trbojevićc-Akmać ...
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Morze, Jakub
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Mihelćcićc, Mate ...
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Cindrićc, Ana
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Liu, Yanyan
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Demler, Olga
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Perola, Markus
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Mora, Samia
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Lauc, Gordan
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Wittenbecher, Cl ...
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