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  • Koistinen, Ville MikaelItä-Suomen Yliopisto,University of Eastern Finland,Turun Yliopisto,University of Turku (author)

Metabolic changes in response to varying whole-grain wheat and rye intake

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • 2024
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:research.chalmers.se:010fd41e-6d73-4a64-8b2e-22597df76a7a
  • https://research.chalmers.se/publication/539823URI
  • https://doi.org/10.1038/s41538-024-00247-0DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Epidemiological studies have shown associations between whole-grain intake and lowered disease risk. A sufficient level of whole-grain intake to reach the health benefits has not been established, and there is limited knowledge about the impact of whole-grain intake on metabolite levels. In this clinical intervention study, we aimed to identify plasma and urine metabolites associated with two different intake levels of whole-grain wheat and rye and to correlate them with clinical plasma biomarkers. Healthy volunteers (N = 68) were divided into two groups receiving either whole-grain wheat or whole-grain rye in two four-week interventions with 48 and 96 g/d of whole grains consumed. The metabolomics of the plasma samples was performed with UPLC–QTOF-MS. Plasma alkylresorcinols were quantified with GC-MS and plasma and urinary mammalian lignans with HPLC-ECD. The high-dose intervention impacted the metabolite profile, including microbial metabolites, more in the rye-enriched diet compared with wheat. Among the increased metabolites were alkylresorcinol glucuronides, sinapyl alcohol, and pipecolic acid betaine, while the decreased metabolites included acylcarnitines and ether lipids. Plasma alkylresorcinols, urinary enterolactone, and total mammalian lignans reflected the study diets in a dose-dependent manner. Several key metabolites linked with whole-grain consumption and gut microbial metabolism increased in a linear manner between the two interventions. The results reveal that an increase in whole-grain intake, particularly rye, is strongly reflected in the metabolite profile, is correlated with clinical variables, and suggests that a diet rich in whole grains promotes the growth and/or metabolism of microbes producing potentially beneficial microbial metabolites.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Haldar, Sumanto (author)
  • Tuomainen, MarjoItä-Suomen Yliopisto,University of Eastern Finland (author)
  • Lehtonen, MarkoItä-Suomen Yliopisto,University of Eastern Finland (author)
  • Klåvus, AntonItä-Suomen Yliopisto,University of Eastern Finland (author)
  • Draper, JohnAberystwyth University (author)
  • Lloyd, AmandaAberystwyth University (author)
  • Beckmann, ManfredAberystwyth University (author)
  • Bal, WendyUniversity of Newcastle upon Tyne (author)
  • Ross, Alastair B.AgResearch,AgResearch Lincoln (author)
  • Brandt, KirstenUniversity of Newcastle upon Tyne (author)
  • Fawcett, LeeUniversity of Newcastle upon Tyne (author)
  • Seal, C. J.University of Newcastle upon Tyne (author)
  • Hanhineva, Kati,1972Turun Yliopisto,University of Turku,Chalmers tekniska högskola,Chalmers University of Technology,Itä-Suomen Yliopisto,University of Eastern Finland(Swepub:cth)kati (author)
  • Itä-Suomen YliopistoTurun Yliopisto (creator_code:org_t)

Related titles

  • In:npj Science of Food8:12396-8370

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