Prospects for systems biology and modeling of the gut microbiome

Karlsson, Fredrik,1984Chalmers tekniska högskola,Chalmers University of Technology (author)

Abundant microorganisms that inhabit the human intestine are implicated in health and disease. The gut microbiome has been studied with metagenomic tools, and over 3 million genes have been discovered, constituting a 'parts list' of this ecosystem; further understanding requires studies of the interacting parts. Mouse models have provided a glimpse into the microbiota and host interactions at metabolic and immunologic levels; however, to provide more insight, there is a need to generate mathematical models that can reveal genotype-phenotype relationships and provide scaffolds for integrated analyses. To this end, we propose the use of genome-scale metabolic models that have successfully been used in studying interactions between human hosts and microbes, as well as microbes in isolation and in communities.

Nookaew, Intawat,1977Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)intawat (author)
Petranovic Nielsen, Dina,1975Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)dinap (author)
Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj (author)
Chalmers tekniska högskola (creator_code:org_t)

By the author/editor: Karlsson, Fredri ...; Nookaew, Intawat ...; Petranovic Niels ...; Nielsen, Jens B, ...

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