Protein post-translational modifications in bacteria

Macek, B.Eberhard Karls Universität Tübingen,Eberhard Karls University of Tübingen (författare)

Over the past decade the number and variety of protein post-translational modifications that have been detected and characterized in bacteria have rapidly increased. Most post-translational protein modifications occur in a relatively low number of bacterial proteins in comparison with eukaryotic proteins, and most of the modified proteins carry low, substoichiometric levels of modification; therefore, their structural and functional analysis is particularly challenging. The number of modifying enzymes differs greatly among bacterial species, and the extent of the modified proteome strongly depends on environmental conditions. Nevertheless, evidence is rapidly accumulating that protein post-translational modifications have vital roles in various cellular processes such as protein synthesis and turnover, nitrogen metabolism, the cell cycle, dormancy, sporulation, spore germination, persistence and virulence. Further research of protein post-translational modifications will fill current gaps in the understanding of bacterial physiology and open new avenues for treatment of infectious diseases.

Forchhammer, KarlEberhard Karls Universität Tübingen,Eberhard Karls University of Tübingen (författare)
Hardouin, JulieUniversite de Rouen,University of Rouen (författare)
Weber-Ban, EilikaEidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH) (författare)
Grangeasse, C.Université de Lyon (författare)
Mijakovic, Ivan,1975Danmarks Tekniske Universitet,Technical University of Denmark,Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)ivanmi (författare)
Eberhard Karls Universität TübingenUniversite de Rouen (creator_code:org_t)

Ingår i:Nature Reviews Microbiology: Springer Science and Business Media LLC17:11, s. 651-6641740-15261740-1534

Av författaren/redakt...: Macek, B.; Forchhammer, Kar ...; Hardouin, Julie; Weber-Ban, Eilik ...; Grangeasse, C.; Mijakovic, Ivan, ...

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