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Dissimilar Deformat...
Dissimilar Deformation of Fluid- and Gel-Phase Liposomes upon Multivalent Interaction with Cell Membrane Mimics Revealed Using Dual-Wavelength Surface Plasmon Resonance
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- Norling, Karin, 1988 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Division of Nano and Biophysics, Department of Physics, Chalmers University of Technology, Gothenburg, Sweden
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- Sjöberg, Mattias, 1991 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Division of Nano and Biophysics, Department of Physics, Chalmers University of Technology, Gothenburg, Sweden
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- Bally, Marta, 1981 (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Umeå University
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- Zhdanov, Vladimir, 1952 (författare)
- Russian Academy of Sciences,Chalmers tekniska högskola,Chalmers University of Technology,Division of Nano and Biophysics, Department of Physics, Chalmers University of Technology, Gothenburg, Sweden; Boreskov Institute of Catalysis, Russian Academy of Sciences, Novosibirsk, Russian Federation
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- Parveen, Nagma, 1988 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Division of Nano and Biophysics, Department of Physics, Chalmers University of Technology, Gothenburg, Sweden
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- Höök, Fredrik, 1966 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Division of Nano and Biophysics, Department of Physics, Chalmers University of Technology, Gothenburg, Sweden
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(creator_code:org_t)
- 2022-02-14
- 2022
- Engelska.
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Ingår i: Langmuir. - : American Chemical Society (ACS). - 1520-5827 .- 0743-7463. ; 38:8, s. 2550-2560
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Abstract
Ämnesord
Stäng
- The mechanical properties of biological nanoparticles play a crucial role in their interaction with the cellular membrane, in particular for cellular uptake. This has significant implications for the design of pharmaceutical carrier particles. In this context, liposomes have become increasingly popular, among other reasons due to their customizability and easily varied physicochemical properties. With currently available methods, it is, however, not trivial to characterize the mechanical properties of nanoscopic liposomes especially with respect to the level of deformation induced upon their ligand-receptor-mediated interaction with laterally fluid cellular membranes. Here, we utilize the sensitivity of dual-wavelength surface plasmon resonance to probe the size and shape of bound liposomes (∼100 nm in diameter) as a means to quantify receptor-induced deformation during their interaction with a supported cell membrane mimic. By comparing biotinylated liposomes in gel and fluid phases, we demonstrate that fluid-phase liposomes are more prone to deformation than their gel-phase counterparts upon binding to the cell membrane mimic and that, as expected, the degree of deformation depends on the number of ligand-receptor pairs that are engaged in the multivalent binding.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
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Norling, Karin, ...
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Sjöberg, Mattias ...
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Bally, Marta, 19 ...
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Zhdanov, Vladimi ...
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Parveen, Nagma, ...
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Höök, Fredrik, 1 ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biokemi och mole ...
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Andra medicinska ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biofysik
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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och Fysikalisk kemi
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Langmuir
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Chalmers tekniska högskola
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Umeå universitet