Search: (hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin)) pers:(Ahrén Bo) >
Effect of Liragluti...
Effect of Liraglutide on Times in Glycaemic Ranges as Assessed by CGM for Type 2 Diabetes Patients Treated With Multiple Daily Insulin Injections
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- Sofizadeh, Sheyda (author)
- Karolinska Institutet,University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,NU Hospital Group
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- Imberg, Henrik, 1991 (author)
- Chalmers University of Technology,Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Statistiska Konsultgruppen
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- Ólafsdóttir, Arndís F. (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,NU Hospital Group
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- Ekelund, Magnus (author)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Novo Nordisk A/S
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- Dahlqvist, S. (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,NU Hospital Group
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- Hirsch, Irl B. (author)
- University of Washington
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- Filipsson, Karin (author)
- Lund University,Lunds universitet,Diabetes lab,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Ahrén, Bo (author)
- Lund University,Lunds universitet,Diabetes,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Sjöberg, Stefan (author)
- Karolinska Institute,Karolinska University Hospital
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- Tuomilehto, Jaako (author)
- National Institute for Health and Welfare,King Abdulaziz University,Helsingin Yliopisto,University of Helsinki,Finnish National Institute for Health and Welfare
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- Lind, Marcus, 1976 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,NU Hospital Group
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(creator_code:org_t)
- 2019-09-28
- 2019
- English.
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In: Diabetes Therapy. - : Springer Science and Business Media LLC. - 1869-6953 .- 1869-6961. ; 10:6, s. 2115-2130
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Abstract
Subject headings
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- Introduction: The effects of the GLP-1 analogue liraglutide on time in hypoglycaemia, time in hyperglycaemia, and time in range for type 2 diabetes patients initially treated with multiple daily insulin injections (MDI) were investigated. Variables associated with hypoglycaemia in the current population were also identified. Methods: Analyses were based on data from a previously performed double-blind, placebo-controlled trial in which 124 MDI-treated patients with type 2 diabetes were randomized to liraglutide or placebo. Masked continuous glucose monitoring (CGM) was performed at baseline and week 24 in 99 participants. Results: The mean time in hypoglycaemia was similar for participants receiving liraglutide and those receiving placebo after 24 weeks of treatment. Mean time in target was greater in the liraglutide group than in the placebo group: 430 versus 244 min/24 h (p < 0.001) and 960 versus 695 min/24 h (p < 0.001) for the two glycaemic ranges considered, 4–7 mmol/l and 4–10 mmol/l, respectively. Mean time in hyperglycaemia was lower in the liraglutide group: 457 versus 723 min/24 h (p = 0.001) and 134 versus 264 min/24 h (p = 0.023) for the two cutoffs considered, > 10 mmol/l and > 14 mmol/l, respectively. Lower mean glucose level, lower C-peptide, and higher glucose variability were associated with an increased risk of hypoglycaemia in both treatment groups. Higher proinsulin level was associated with a lower risk of hypoglycaemia in the liraglutide group. Conclusion: For type 2 diabetes patients initially treated with MDI, introducing liraglutide had a beneficial effect on glucose profiles estimated by masked CGM. Mean glucose level, glycaemic variability, C-peptide, and proinsulin level influenced the risk of hypoglycaemia in this population. Trial Registration: ClinicalTrials.gov, number (EudraCT nr: 2012-001941-42). Funding: Novo Nordisk funded this study. The Diabetes Research Unit, NU-Hospital Group funded the journal’s Rapid Service Fee.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Placebo
- Hyperglycaemia
- Time in range
- Liraglutide
- Continuous glucose monitoring
- Type 2 diabetes mellitus
- Hypoglycaemia
- Randomized clinical trial
- Continuous glucose monitoring
- Hyperglycaemia
- Hypoglycaemia
- Liraglutide
- Placebo
- Randomized clinical trial
- Time in range
- Type 2 diabetes mellitus
Publication and Content Type
- art (subject category)
- ref (subject category)
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Sofizadeh, Sheyd ...
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Imberg, Henrik, ...
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Ólafsdóttir, Arn ...
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Ekelund, Magnus
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Dahlqvist, S.
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Hirsch, Irl B.
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Filipsson, Karin
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Ahrén, Bo
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Sjöberg, Stefan
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Tuomilehto, Jaak ...
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Lind, Marcus, 19 ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and General Practice
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Diabetes Therapy
- By the university
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Chalmers University of Technology
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University of Gothenburg
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Lund University
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Karolinska Institutet