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  • Pivodic, Aldina,1978Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Ophthalmol, S-41685 Gothenburg, Sweden;Stat Konsultgrp, Gothenburg, Sweden (författare)

Individual Risk Prediction for Sight-Threatening Retinopathy of Prematurity Using Birth Characteristics

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • American Medical Association (AMA),2020
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:research.chalmers.se:153361c4-3cd5-4592-8aec-00b9bce60950
  • https://research.chalmers.se/publication/513957URI
  • https://doi.org/10.1001/jamaophthalmol.2019.4502DOI
  • https://gup.ub.gu.se/publication/287927URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-403498URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Importance: To prevent blindness, repeated infant eye examinations are performed to detect severe retinopathy of prematurity (ROP), yet only a small fraction of those screened need treatment. Early individual risk stratification would improve screening timing and efficiency and potentially reduce the risk of blindness. Objectives: To create and validate an easy-to-use prediction model using only birth characteristics and to describe a continuous hazard function for ROP treatment. Design, Setting, and Participants: In this retrospective cohort study, Swedish National Patient Registry data from infants screened for ROP (born between January 1, 2007, and August 7, 2018) were analyzed with Poisson regression for time-varying data (postnatal age, gestational age [GA], sex, birth weight, and important interactions) to develop an individualized predictive model for ROP treatment (called DIGIROP-Birth [Digital ROP]). The model was validated internally and externally (in US and European cohorts) and compared with 4 published prediction models. Main Outcomes and Measures: The study outcome was ROP treatment. The measures were estimated momentary and cumulative risks, hazard ratios with 95% CIs, area under the receiver operating characteristic curve (hereinafter referred to as AUC), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Results: Among 7609 infants (54.6% boys; mean [SD] GA, 28.1 [2.1] weeks; mean [SD] birth weight, 1119 [353] g), 442 (5.8%) were treated for ROP, including 142 (40.1%) treated of 354 born at less than 24 gestational weeks. Irrespective of GA, the risk for receiving ROP treatment increased during postnatal weeks 8 through 12 and decreased thereafter. Validations of DIGIROP-Birth for 24 to 30 weeks' GA showed high predictive ability for the model overall (AUC, 0.90 [95% CI, 0.89-0.92] for internal validation, 0.94 [95% CI, 0.90-0.98] for temporal validation, 0.87 [95% CI, 0.84-0.89] for US external validation, and 0.90 [95% CI, 0.85-0.95] for European external validation) by calendar periods and by race/ethnicity. The sensitivity, specificity, PPV, and NPV were numerically at least as high as those obtained from CHOP-ROP (Children's Hospital of Philadelphia-ROP), OMA-ROP (Omaha-ROP), WINROP (weight, insulinlike growth factor 1, neonatal, ROP), and CO-ROP (Colorado-ROP), models requiring more complex postnatal data. Conclusions and Relevance: This study validated an individualized prediction model for infants born at 24 to 30 weeks' GA, enabling early risk prediction of ROP treatment based on birth characteristics data. Postnatal age rather than postmenstrual age was a better predictive variable for the temporal risk of ROP treatment. The model is an accessible online application that appears to be generalizable and to have at least as good test statistics as other models requiring longitudinal neonatal data not always readily available to ophthalmologists.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hård, Anna LenaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Ophthalmol, S-41685 Gothenburg, Sweden (författare)
  • Löfqvist, Chatarina,1964Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institutionen för vårdvetenskap och hälsa,Institute of Neuroscience and Physiology,Institute of Health and Care Sciences,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Ophthalmol, S-41685 Gothenburg, Sweden;Univ Gothenburg, Sahlgrenska Acad, Inst Hlth Care Sci, Gothenburg, Sweden(Swepub:gu)xlofch (författare)
  • Smith, Lois E.H.Children's Hospital Boston,Harvard Med Sch, Boston Childrens Hosp, Dept Ophthalmol, Boston, MA 02115 USA (författare)
  • Wu, CarolynChildren's Hospital Boston,Harvard Med Sch, Boston Childrens Hosp, Dept Ophthalmol, Boston, MA 02115 USA (författare)
  • Bründer, Marie ChristineUniversitätsmedizin Greifswald,Greifswald University Hospital,Univ Med Ctr Greifswald, Dept Ophthalmol, Greifswald, Germany (författare)
  • Lagrèze, Wolf A.Albert-Ludwigs-Universität Freiburg,University of Freiburg,Univ Freiburg, Eye Ctr, Med Ctr, Fac Med, Freiburg, Germany (författare)
  • Stahl, AndreasUniversitätsmedizin Greifswald,Greifswald University Hospital,Univ Med Ctr Greifswald, Dept Ophthalmol, Greifswald, Germany (författare)
  • Holmström, Gerd,1951-Uppsala universitet,Söderberg: Oftalmiatrik(Swepub:uu)gerdholm (författare)
  • Albertsson-Wikland, Kerstin,1947Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Physiol,Unit Endocrinol, Gothenburg, Sweden(Swepub:gu)xalbke (författare)
  • Johansson, Helena,1981Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Australian Catholic Univ, McKillop Hlth Inst, Melbourne, Vic, Australia;Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Publ Hlth & Community Med, Gothenburg, Sweden(Swepub:gu)xjhell (författare)
  • Nilsson, Staffan,1956Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Institutionen för biomedicin,Department of Mathematical Sciences,Institute of Biomedicine,Chalmers Univ Technol, Math Sci, Gothenburg, Sweden;Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Gothenburg, Sweden(Swepub:gu)xnista (författare)
  • Hellström, Ann,1959Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Ophthalmol, S-41685 Gothenburg, Sweden(Swepub:gu)xheann (författare)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:JAMA Ophthalmology: American Medical Association (AMA)138:1, s. 21-292168-61652168-6173

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