Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy

Martins, Murillo L.Universidade Estadual Paulista (UNESP),São Paulo State University (UNESP),Niels Bohr Institute (författare)

The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.

Orecchini, A.Universita degli Studi di Perugia,University of Perugia,Institut Laue-Langevin (författare)
Aguilera Medina, Luis,1983Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)aguilera (författare)
Eckert, JuergenUniversity of South Florida (författare)
Embs, J.P.Paul Scherrer Institut (författare)
Matic, Aleksandar,1968Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)matic (författare)
Saeki, M.J.Universidade Estadual Paulista (UNESP),São Paulo State University (UNESP) (författare)
Bordallo, Heloisa N.Niels Bohr Institute (författare)
Universidade Estadual Paulista (UNESP)Niels Bohr Institute (creator_code:org_t)

Av författaren/redakt...: Martins, Murillo ...; Orecchini, A.; Aguilera Medina, ...; Eckert, Juergen; Embs, J.P.; Matic, Aleksanda ...; visa fler...; Saeki, M.J.; Bordallo, Helois ...; visa färre...

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