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Modelling the cost-...
Modelling the cost-benefit impact of integrated product modularisation and postponement in the supply chain for pharmaceutical mass customisation
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- Siiskonen, Maria Daniela Irene, 1990 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Govender, Rydvikha, 1989 (author)
- AstraZeneca AB
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- Malmqvist, Johan, 1964 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Folestad, Staffan, 1954 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Journal of Engineering Design. - 1466-1837 .- 0954-4828. ; 34:10, s. 865-896
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https://research.cha... (primary) (free)
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https://doi.org/10.1...
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Abstract
Subject headings
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- Realisation of pharmaceutical product and production systems capable of delivering product customisation cost-effectively is essential for adding value to patients and society through improved tailoring of therapies to individuals relative to current mass-produced products. To address the continued lack of evidence-based system solutions, this study presents a holistic design framework and a novel computational platform for enabling design explorations of integrated pharmaceutical product and supply chain (SC) reconfiguration. The design and modelling framework developed herein takes an end-to-end SC perspective, adapts the mass customisation strategies of product modularisation and postponement, and demonstrates case study simulations based on real-life therapy and SC archetypes. The cost-effectiveness assessment with the derived integrated systems computational platform confirm that product modularisation drives patient benefit through variety provision and that postponement drives cost reduction in an end-to-end SC. A novel insight is therefore that both product modularisation and postponement, in an integrated manner, are required for maximising cost-effective customisation. Moreover, the computational simulations, founded and modelled on real-life scenarios, provide design requirements for reconfigurable product and SC systems in a pharmaceutical context. In all, these findings are imperative for providing guidance on integrated pharmaceutical product and production systems design and mass customisation/ mass personalisation/mass individualisation realisation.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Maskinteknik -- Produktionsteknik, arbetsvetenskap och ergonomi (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Mechanical Engineering -- Production Engineering, Human Work Science and Ergonomics (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Maskinteknik -- Annan maskinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Mechanical Engineering -- Other Mechanical Engineering (hsv//eng)
Keyword
- supply chain modelling
- mass customisation
- Design methodology
- concurrent engineering
- computational platform
Publication and Content Type
- art (subject category)
- ref (subject category)
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