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Cerebral biomarkers...
Cerebral biomarkers in neurologic complications of preeclampsia
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- Bergman, Lina, 1982 (author)
- Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Klinisk obstetrik,Stellenbosch Univ, Dept Obstet & Gynecol, Cape Town, South Africa.;Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Obstet & Gynecol, Gothenburg, Sweden.
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- Hastie, Roxanne (author)
- University of Melbourne,Mercy Hospital for Women,Univ Melbourne, Dept Obstet & Gynaecol, Translat Obstet Grp, Melbourne, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
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- Bokström-Rees, Emma (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Obstet & Gynecol, Gothenburg, Sweden.
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Mölndal, Sweden.;Sahlgrens Univ Hosp, Clin Neurochem Lab, Mölndal, Sweden.;UCL, Dept Neurodegenerat Dis, Inst Neurol, Queen Sq, London, England.;United Kingdom Dementia Res Inst, London, England.;Hong Kong Ctr Neurodegenerat Dis, Hong Kong, Peoples R China.
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Mölndal, Sweden.;Sahlgrens Univ Hosp, Clin Neurochem Lab, Mölndal, Sweden.
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- Schell, Sonja (author)
- Universiteit Stellenbosch,Stellenbosch University,Stellenbosch Univ, Dept Obstet & Gynecol, Cape Town, South Africa.
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- Imberg, Henrik, 1991 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Stat Konsultgruppen, Gothenburg, Sweden.;Chalmers Univ Technol, Dept Math Sci, Gothenburg, Sweden.;Univ Gothenburg, Gothenburg, Sweden.
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- Langenegger, Eduard (author)
- Universiteit Stellenbosch,Stellenbosch University,Stellenbosch Univ, Dept Obstet & Gynecol, Cape Town, South Africa.
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- Moodley, Ashley (author)
- Universiteit Stellenbosch,Stellenbosch University,Stellenbosch Univ, Dept Obstet & Gynecol, Cape Town, South Africa.
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- Walker, Susan (author)
- University of Melbourne,Mercy Hospital for Women,Univ Melbourne, Dept Obstet & Gynaecol, Translat Obstet Grp, Melbourne, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
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- Tong, Stephen (author)
- University of Melbourne,Mercy Hospital for Women,Univ Melbourne, Dept Obstet & Gynaecol, Translat Obstet Grp, Melbourne, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
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- Cluver, Catherine (author)
- Mercy Hospital for Women,Universiteit Stellenbosch,Stellenbosch University,University of Melbourne,Stellenbosch Univ, Dept Obstet & Gynecol, Cape Town, South Africa.;Univ Melbourne, Dept Obstet & Gynaecol, Translat Obstet Grp, Melbourne, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: American Journal of Obstetrics and Gynecology. - : Elsevier BV. - 0002-9378 .- 1097-6868. ; 227:2, s. 298.e1-298.e10
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Abstract
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- Background: There is no tool to accurately predict who is at risk of developing neurologic complications of preeclampsia, and there is no objective method to determine disease severity. Objective: We assessed whether plasma concentrations of the cerebral biomarkers neurofilament light, tau, and glial fibrillary acidic protein could reflect disease severity in several phenotypes of preeclampsia. Furthermore, we compared the cerebral biomarkers with the angiogenic biomarkers soluble fms-like tyrosine kinase 1, placental growth factor, and soluble endoglin. Study Design: In this observational study, we included women from the South African Preeclampsia Obstetric Adverse Events biobank. Plasma samples taken at diagnosis (preeclampsia cases) or admission for delivery (normotensive controls) were analyzed for concentrations of neurofilament light, tau, glial fibrillary acidic protein, placental growth factor, soluble fms-like tyrosine kinase 1, and soluble endoglin. The cerebrospinal fluid concentrations of inflammatory markers and albumin were analyzed in a subgroup of 15 women. Analyses were adjusted for gestational age, time from seizures and delivery to sampling, maternal age, and parity. Results: Compared with 28 women with normotensive pregnancies, 146 women with preeclampsia demonstrated 2.18-fold higher plasma concentrations of neurofilament light (95% confidence interval, 1.64–2.88), 2.17-fold higher tau (95% confidence interval, 1.49–3.16), and 2.77-fold higher glial fibrillary acidic protein (95% confidence interval, 2.06–3.72). Overall, 72 women with neurologic complications (eclampsia, cortical blindness, and stroke) demonstrated increased plasma concentrations of tau (2.99-fold higher; 95% confidence interval, 1.92–4.65) and glial fibrillary acidic protein (3.22-fold higher; 95% confidence interval, 2.06–5.02) compared with women with preeclampsia without pulmonary edema; hemolysis, elevated liver enzymes, and low platelet count; or neurologic complications (n=31). Moreover, angiogenic markers were higher, but to a lesser extent. Women with hemolysis, elevated liver enzymes, and low platelet count (n=20) demonstrated increased plasma concentrations of neurofilament light (1.64-fold higher; 95% confidence interval, 1.06–2.55), tau (4.44-fold higher; 95% confidence interval, 1.85–10.66), and glial fibrillary acidic protein (1.82-fold higher; 95% confidence interval, 1.32–2.50) compared with women with preeclampsia without pulmonary edema; hemolysis, elevated liver enzymes, and low platelet count; or neurologic complications. There was no difference shown in the angiogenic biomarkers. There was no difference between 23 women with preeclampsia complicated by pulmonary edema and women with preeclampsia without pulmonary edema; hemolysis, elevated liver enzymes, and low platelet count; or neurologic complications for any of the biomarkers. Plasma concentrations of tau and glial fibrillary acidic protein were increased in women with several neurologic complications compared with women with eclampsia only. Conclusion: Plasma neurofilament light, glial fibrillary acidic, and tau were candidate biomarkers for the diagnosis and possibly prediction of cerebral complications of preeclampsia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- eclampsia
- preeclampsia
- glial fibrillary acid protein
- tau
- neurofilament light
- prediction
- cerebral biomarkers
Publication and Content Type
- art (subject category)
- ref (subject category)
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Bergman, Lina, 1 ...
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Hastie, Roxanne
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Bokström-Rees, E ...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Schell, Sonja
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Imberg, Henrik, ...
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Langenegger, Edu ...
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Moodley, Ashley
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Walker, Susan
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Tong, Stephen
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Cluver, Catherin ...
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MEDICAL AND HEAL ...
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Chalmers University of Technology
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University of Gothenburg
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Uppsala University