Sustained release of nucleic acids from polymeric nanoparticles using microemulsion precipitation in supercritical carbon dioxide

• A general approach for producing biodegradable nanoparticles for sustained nucleic acid release is presented. The nanoparticles are produced by precipitating a water-in-oil microemulsion in supercritical CO2. The microemulsion consists of a transfer RNA aqueous solution (water phase), dichloromethane containing poly(L-lactic acid)-poly(ethylene glycol) (oil phase), the surfactant n-octyl beta-D-glucopyranoside, and the cosurfactant n-butanol.

Ämnesord

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Nyckelord

rna

emulsions

interference

microspheres

in-vivo

mechanism

sirna

delivery

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)