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Global analysis of ...
Global analysis of biosynthetic gene clusters reveals vast potential of secondary metabolite production in Penicillium species
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- Froslev Nielsen, Jens Christian, 1987 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers, Dept Biol & Biol Engn, SE-41296 Gothenburg, Sweden.;Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, DK-2800 Lyngby, Denmark.
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- Grijseels, S. (författare)
- Danmarks Tekniske Universitet,Technical University of Denmark,Tech Univ Denmark, Dept Biotechnol & Biomed, DK-2800 Lyngby, Denmark.
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- Prigent, Sylvain, 1984 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers, Dept Biol & Biol Engn, SE-41296 Gothenburg, Sweden.
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- Ji, Boyang, 1983 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers, Dept Biol & Biol Engn, SE-41296 Gothenburg, Sweden.
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- Dainat, Jacques (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Nielsen, K. F. (författare)
- Danmarks Tekniske Universitet,Technical University of Denmark,Tech Univ Denmark, Dept Biotechnol & Biomed, DK-2800 Lyngby, Denmark.
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- Frisvad, J. C. (författare)
- Danmarks Tekniske Universitet,Technical University of Denmark,Tech Univ Denmark, Dept Biotechnol & Biomed, DK-2800 Lyngby, Denmark.
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- Workman, M. (författare)
- Danmarks Tekniske Universitet,Technical University of Denmark,Tech Univ Denmark, Dept Biotechnol & Biomed, DK-2800 Lyngby, Denmark.
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- Nielsen, Jens B, 1962 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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Chalmers tekniska högskola Chalmers, Dept Biol & Biol Engn, SE-41296 Gothenburg, Sweden;Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, DK-2800 Lyngby, Denmark. (creator_code:org_t)
- 2017-04-03
- 2017
- Engelska.
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Ingår i: Nature Microbiology. - : Springer Science and Business Media LLC. - 2058-5276. ; 2:6
- Relaterad länk:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://research.cha...
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https://urn.kb.se/re...
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Abstract
Ämnesord
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- Filamentous fungi produce a wide range of bioactive compounds with important pharmaceutical applications, such as antibiotic penicillins and cholesterol-lowering statins. However, less attention has been paid to fungal secondary metabolites compared to those from bacteria. In this study, we sequenced the genomes of 9 Penicillium species and, together with 15 published genomes, we investigated the secondary metabolism of Penicillium and identified an immense, unexploited potential for producing secondary metabolites by this genus. A total of 1,317 putative biosynthetic gene clusters (BGCs) were identified, and polyketide synthase and non-ribosomal peptide synthetase based BGCs were grouped into gene cluster families and mapped to known pathways. The grouping of BGCs allowed us to study the evolutionary trajectory of pathways based on 6-methylsalicylic acid (6-MSA) synthases. Finally, we cross-referenced the predicted pathways with published data on the production of secondary metabolites and experimentally validated the production of antibiotic yanuthones in Penicillia and identified a previously undescribed compound from the yanuthone pathway. This study is the first genus-wide analysis of the genomic diversity of Penicillia and highlights the potential of these species as a source of new antibiotics and other pharmaceuticals.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Froslev Nielsen, ...
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Grijseels, S.
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Prigent, Sylvain ...
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Ji, Boyang, 1983
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Dainat, Jacques
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Nielsen, K. F.
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visa fler...
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Frisvad, J. C.
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Workman, M.
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Nielsen, Jens B, ...
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Mikrobiologi
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MEDICIN OCH HÄLS ...
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och Mikrobiologi ino ...
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Nature Microbiol ...
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Chalmers tekniska högskola
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Uppsala universitet