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Retinol and Retinol...
Retinol and Retinol Binding Protein 4 Levels and Cardiometabolic Disease Risk
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- Schiborn, Catarina (author)
- Deutsches Zentrum für Diabetesforschung (DZD) (DZD),German Center for Diabetes Research (DZD),Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE),German Institute of Human Nutrition Potsdam-Rehbrucke (DIfE)
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- Weber, Daniela (author)
- Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE),German Institute of Human Nutrition Potsdam-Rehbrucke (DIfE)
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- Grune, Tilman (author)
- Deutsches Zentrum für Herz-Kreislauf-Forshung (DZHK),German Center for Cardiovascular Research DZHK,Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE),German Institute of Human Nutrition Potsdam-Rehbrucke (DIfE)
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- Biemann, Ronald (author)
- Universitatsklinikum Leipzig und Medizinische Fakultat,Leipzig University Hospital
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- Jager, Susanne (author)
- Deutsches Zentrum für Diabetesforschung (DZD) (DZD),German Center for Diabetes Research (DZD),Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE),German Institute of Human Nutrition Potsdam-Rehbrucke (DIfE)
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- Neu, Natascha (author)
- Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE),German Institute of Human Nutrition Potsdam-Rehbrucke (DIfE)
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- von Blumencron, Marie Muller (author)
- Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE),German Institute of Human Nutrition Potsdam-Rehbrucke (DIfE)
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- Fritsche, Andreas (author)
- Eberhard Karls Universität Tübingen,Eberhard Karls University of Tübingen,Deutsches Zentrum für Diabetesforschung (DZD) (DZD),German Center for Diabetes Research (DZD)
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- Weikert, Cornelia (author)
- German Federal Institute for Risk Assessment
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- Schulze, Matthias B. (author)
- Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE),German Institute of Human Nutrition Potsdam-Rehbrucke (DIfE),Deutsches Zentrum für Diabetesforschung (DZD) (DZD),German Center for Diabetes Research (DZD),Universität Potsdam,University of Potsdam
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- Wittenbecher, Clemens, 1981 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2022
- 2022
- English.
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In: Circulation Research. - 1524-4571 .- 0009-7330. ; 131:7, s. 637-649
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Abstract
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- Background: Despite mechanistic studies linking retinol and RBP4 (retinol binding protein 4) to the pathogenesis of cardiovascular diseases (CVD) and type 2 diabetes (T2D), epidemiological evidence is still conflicting. We investigated whether conflicting results of previous studies may be explained by differences in the association of retinol and RBP4 with cardiometabolic risk across subgroups with distinct sex, hypertension state, liver, or kidney function. Methods: We used case-cohorts nested in the EPIC (European Prospective Investigation Into Cancer and Nutrition)-Potsdam cohort (N=27 548) comprising a random sample of participants (n=2500) and all physician-verified cases of incident CVD (n=508, median follow-up time 8.2 years) and T2D (n=820, median follow-up time 6.3 years). We estimated nonlinear and linear multivariable-adjusted associations between the biomarkers and cardiometabolic diseases by restricted cubic splines and Cox regression, respectively, testing potential interactions with hypertension, liver, and kidney function. Additionally, we performed 2-sample Mendelian Randomization analyses in publicly available data. Results: The association of retinol with cardiometabolic risk was modified by hypertension state (P interaction CVDP interaction T2D<0.001). Retinol was associated with lower cardiometabolic risk in participants with treated hypertension (hazard ratio(per SD) [95% CI]: CVD, 0.71 [0.56-0.90]; T2D, 0.81 [0.70-0.94]) but with higher cardiometabolic risk in normotensive participants (CVD, 1.32 [1.06-1.64]; T2D, 1.15 [0.98-1.36]). Our analyses also indicated a significant interaction between RBP4 and hypertension on CVD risk (P interaction=0.04). Regarding T2D risk, we observed a u-shaped association with RBP4 in women (P nonlinearity=0.01, P effect=0.02) and no statistically significant association in men. The biomarkers' interactions with liver or kidney function were not statistically significant. Hypertension state-specific associations for retinol concentrations with cardiovascular mortality risk were replicated in National Health and Nutrition Examination Survey III. Conclusions: Our findings suggest a hypertension-dependent relationship between plasma retinol and cardiometabolic risk and complex interactions of RBP4 with sex and hypertension on cardiometabolic risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- risk
- lipoprotein
- hypertension
- myocardial infarction
- cardiovascular diseases
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Schiborn, Catari ...
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Weber, Daniela
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Grune, Tilman
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Biemann, Ronald
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Jager, Susanne
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Neu, Natascha
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von Blumencron, ...
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Fritsche, Andrea ...
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Weikert, Corneli ...
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Schulze, Matthia ...
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Wittenbecher, Cl ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and General Practice
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
- Articles in the publication
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Circulation Rese ...
- By the university
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Chalmers University of Technology