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Defining the human ...
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Blockhuys, Stephanie,1983Chalmers tekniska högskola,Chalmers University of Technology,Department Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
(författare)
Defining the human copper proteome and analysis of its expression variation in cancers.
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2017
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Oxford University Press (OUP),2017
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:research.chalmers.se:2f04d8f0-a500-4cf4-96c0-15da3fa4393a
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https://doi.org/10.1039/c6mt00202aDOI
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https://research.chalmers.se/publication/246458URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-135375URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Funding agencies: Swedish Society for Medical Research; Folke and Marianne Edler Research Fund; Lars Hierta Memorial Foundation; Knut and Alice Wallenberg Foundation; Swedish Research Council; Chalmers Foundation; NBIS (National Bioinformatics Infrastructure Sweden)
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Copper (Cu) is essential for living organisms, and acts as a cofactor in many metabolic enzymes. To avoid the toxicity of free Cu, organisms have specific transport systems that 'chaperone' the metal to targets. Cancer progression is associated with increased cellular Cu concentrations, whereby proliferative immortality, angiogenesis and metastasis are cancer hallmarks with defined requirements for Cu. The aim of this study is to gather all known Cu-binding proteins and reveal their putative involvement in cancers using the available database resources of RNA transcript levels. Using the database along with manual curation, we identified a total of 54 Cu-binding proteins (named the human Cu proteome). Next, we retrieved RNA expression levels in cancer versus normal tissues from the TCGA database for the human Cu proteome in 18 cancer types, and noted an intricate pattern of up- and downregulation of the genes in different cancers. Hierarchical clustering in combination with bioinformatics and functional genomics analyses allowed for the prediction of cancer-related Cu-binding proteins; these were specifically inspected for the breast cancer data. Finally, for the Cu chaperone ATOX1, which is the only Cu-binding protein proposed to have transcription factor activities, we validated its predicted over-expression in patient breast cancer tissue at the protein level. This collection of Cu-binding proteins, with RNA expression patterns in different cancers, will serve as an excellent resource for mechanistic-molecular studies of Cu-dependent processes in cancer.
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Celauro, Emanuele,1980Chalmers tekniska högskola,Chalmers University of Technology,Department Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden(Swepub:cth)celauro
(författare)
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Hildesjö, Camilla,1969-Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Klinisk patologi(Swepub:liu)camfr57
(författare)
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Feizi, Amir,1980Chalmers tekniska högskola,Chalmers University of Technology,Department Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden(Swepub:cth)feizi
(författare)
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Stål, Olle,1952-Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US(Swepub:liu)ollst87
(författare)
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Fierro González, Juan Carlos,1979Chalmers tekniska högskola,Chalmers University of Technology,Department Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden(Swepub:cth)juancar
(författare)
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Wittung Stafshede, Pernilla,1968Chalmers tekniska högskola,Chalmers University of Technology,Department Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden(Swepub:cth)perwit
(författare)
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Chalmers tekniska högskolaDepartment Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Metallomics: Oxford University Press (OUP)9:2, s. 112-1231756-59011756-591X
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