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3D Printed Conducti...
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Bordoni, Matteo
(författare)
3D Printed Conductive Nanocellulose Scaffolds for the Differentiation of Human Neuroblastoma Cells
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-03-11
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MDPI AG,2020
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:research.chalmers.se:3baf4328-4319-4c97-afc9-219b004a6be6
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https://research.chalmers.se/publication/517129URI
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https://doi.org/10.3390/cells9030682DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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We prepared cellulose nanofibrils-based (CNF), alginate-based and single-walled carbon nanotubes (SWCNT)-based inks for freeform reversible embedding hydrogel (FRESH) 3D bioprinting of conductive scaffolds. The 3D printability of conductive inks was evaluated in terms of their rheological properties. The differentiation of human neuroblastoma cells (SH-SY5Y cell line) was visualized by the confocal microscopy and the scanning electron microscopy techniques. The expression of TUBB3 and Nestin genes was monitored by the RT-qPCR technique. We have demonstrated that the conductive guidelines promote the cell differentiation, regardless of using differentiation factors. It was also shown that the electrical conductivity of the 3D printed scaffolds could be tuned by calcium-induced crosslinking of alginate, and this plays a significant role on neural cell differentiation. Our work provides a protocol for the generation of a realistic in vitro 3D neural model and allows for a better understanding of the pathological mechanisms of neurodegenerative diseases.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Karabulut, Erdem,1983Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)erdemk
(författare)
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Kuzmenko, Volodymyr,1987Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)kuzmenko
(författare)
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Fantini, ValentinaUniversita degli studi di Pavia
(författare)
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Pansarasa, Orietta
(författare)
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Cereda, Cristina
(författare)
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Gatenholm, Paul,1956Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)gatenh
(författare)
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Chalmers tekniska högskolaUniversita degli studi di Pavia
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cells: MDPI AG9:32073-4409
Internetlänk
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Cells
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