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  • Mellström, Dan,1945Göteborgs universitet,University of Gothenburg (author)

Older men with low serum estradiol and high serum SHBG have an increased risk of fractures

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • 2008-06-02
  • Wiley,2008

Numbers

  • LIBRIS-ID:oai:research.chalmers.se:3f7c838f-37de-479c-a8b3-bcf7b069f05a
  • https://research.chalmers.se/publication/242155URI
  • https://doi.org/10.1359/jbmr.080518DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-98737URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Osteoporosis-related fractures constitute a major health concern not only in women but also in men. To study the predictive role of serum sex steroids for fracture risk in men, serum sex steroids were analyzed by the specific gas chromatography-mass spectrometry technique at baseline in older men (n = 2639; mean, 75 yr of age) of the prospective population-based MrOS Sweden cohort. Fractures occurring after baseline were validated (average follow-up of 3.3 yr). The incidence for having at least one validated fracture after baseline was 20.9/1000 person-years. Estradiol (E2; hazard ratio [HR] per SD decrease, 1.34; 95% CI, 1.22-1.49), free estradiol (fE2; HR per SD decrease, 1.41; 95% CI, 1.28-1.55), testosterone (T; HR per SD decrease, 1.27; 95% CI, 1.16-1.39), and free testosterone (fT; HR per SD decrease, 1.32; 95% CI, 1.21-1.44) were all inversely, whereas sex hormone-binding globulin (SHBG; HR per SD increase, 1.41; 95% CI, 1.22-1.63) was directly related to fracture risk. Multivariable proportional hazards regression models, adjusted for age, suggested that fE2 and SHBG (p

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Vandenput, Liesbeth,1974Göteborgs universitet,University of Gothenburg (author)
  • Mallmin, HansUppsala universitet,Ortopedi(Swepub:uu)hansmall (author)
  • Holmberg, A. H. (author)
  • Lorentzon, Mattias,1970Göteborgs universitet,University of Gothenburg (author)
  • Odén, Anders,1942 (author)
  • Johansson, HelenaGöteborgs universitet,University of Gothenburg (author)
  • Orwoll, E. S. (author)
  • Labrie, F. (author)
  • Karlsson, Magnus K (author)
  • Ljunggren, O. (author)
  • Ohlsson, Claes,1965Göteborgs universitet,University of Gothenburg (author)
  • Göteborgs universitetOrtopedi (creator_code:org_t)

Related titles

  • In:J Bone Miner Res: Wiley23:10, s. 1552-601523-46810884-0431
  • In:Journal of Bone and Mineral Research: Wiley23:10, s. 1552-600884-0431

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