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Designing and interpreting 'multi-omic' experiments that may change our understanding of biology

Haas, Robert (author)
The Francis Crick Institute
Zelezniak, Aleksej, 1984 (author)
The Francis Crick Institute,Chalmers tekniska högskola,Chalmers University of Technology
Iacovacci, Jacopo (author)
The Francis Crick Institute,Imperial College of Science, Technology and Medicine
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Kamrad, Stephan (author)
University College London (UCL),The Francis Crick Institute
Townsend, St John (author)
The Francis Crick Institute,University College London (UCL)
Ralser, M. (author)
The Francis Crick Institute,University Of Cambridge
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 (creator_code:org_t)
Elsevier BV, 2017
2017
English.
In: Current Opinion in Systems Biology. - : Elsevier BV. - 2452-3100. ; 6, s. 37-45
  • Research review (peer-reviewed)
Abstract Subject headings
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  • Most biological mechanisms involve more than one type of biomolecule, and hence operate not solely at the level of either genome, transcriptome, proteome, metabolome or ionome. Datasets resulting from single-omic analysis are rapidly increasing in throughput and quality, rendering multi-omic studies feasible. These should offer a comprehensive, structured and interactive overview of a biological mechanism. However, combining single-omic datasets in a meaningful manner has so far proved challenging, and the discovery of new biological information lags behind expectation. One reason is that experiments conducted in different laboratories can typically not to be combined without restriction. Second, the interpretation of multi-omic datasets represents a significant challenge by nature, as the biological datasets are heterogeneous not only for technical, but also for biological, chemical, and physical reasons. Here, multi-layer network theory and methods of artificial intelligence might contribute to solve these problems. For the efficient application of machine learning however, biological datasets need to become more systematic, more precise - and much larger. We conclude our review with basic guidelines for the successful set-up of a multi-omic experiment.

Subject headings

NATURVETENSKAP  -- Data- och informationsvetenskap -- Medieteknik (hsv//swe)
NATURAL SCIENCES  -- Computer and Information Sciences -- Media and Communication Technology (hsv//eng)
NATURVETENSKAP  -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
NATURAL SCIENCES  -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
NATURVETENSKAP  -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)

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