Sökning: WFRF:(Maj Michal) >
Protein cohabitatio...
Protein cohabitation: long-term immunoglobulin G storage at room temperature
-
- Bharmoria, Pankaj, 1985 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Univ Gothenburg, Dept Chem & Mol Biol, Kemigarden 10, S-41296 Gothenburg, Sweden.;Chalmers Univ Technol, Dept Chem & Chem Engn, Kemivagen 4, S-41296 Gothenburg, Sweden.;ICMAB CSIC, Inst Mat Sci Barcelona, Barcelona 08193, Spain.
-
- Ooi, Saik Ann (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Univ Gothenburg, Dept Chem & Mol Biol, Kemigarden 10, S-41296 Gothenburg, Sweden.
-
- Cellini, Andrea (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Univ Gothenburg, Dept Chem & Mol Biol, Kemigarden 10, S-41296 Gothenburg, Sweden.
-
visa fler...
-
- Tietze, Daniel, 1980 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Univ Gothenburg, Dept Chem & Mol Biol, Kemigarden 10, S-41296 Gothenburg, Sweden.
-
- Maj, Michał (författare)
- Uppsala universitet,Fysikalisk kemi,Strukturbiologi,Angstrom Lab, Dept Chem, Phys Chem, Lagerhyddsvagen 1, S-75120 Uppsala, Sweden.
-
- Moth-Poulsen, Kasper, 1978 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Institut de Ciència de Materials de Barcelona (ICMAB-CSIC),Institute of Material Science of Barcelona (ICMAB),Institucio Catalana de Recerca i Estudis Avancats (ICREA),Catalan Institution for Research and Advanced Studies (ICREA),Universitat Politecnica de Catalunya,Polytechnic University of Catalonia,Chalmers Univ Technol, Dept Chem & Chem Engn, Kemivagen 4, S-41296 Gothenburg, Sweden.;ICMAB CSIC, Inst Mat Sci Barcelona, Barcelona 08193, Spain.;ICREA, Catalan Inst Res & Adv Studies, Pg Lluis Co 23, Barcelona, Spain.;Univ Politecn Cataluna, EEBE, Dept Chem Engn, Eduard Maristany 10-14, Barcelona 08019, Spain.
-
- Tietze, Alesia A., 1984 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Univ Gothenburg, Dept Chem & Mol Biol, Kemigarden 10, S-41296 Gothenburg, Sweden.
-
visa färre...
-
(creator_code:org_t)
- Royal Society of Chemistry, 2023
- 2023
- Engelska.
-
Ingår i: Journal of Materials Chemistry B. - : Royal Society of Chemistry. - 2050-750X .- 2050-7518. ; 11:24, s. 5400-5405
- Relaterad länk:
-
https://research.cha... (primary) (free)
-
visa fler...
-
https://doi.org/10.1...
-
https://uu.diva-port... (primary) (Raw object)
-
https://research.cha...
-
https://doi.org/10.1...
-
https://gup.ub.gu.se...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Long-term functional storage of therapeutic proteins at room temperature has been an eternal challenge. Inspired by the cellular cooperativity of proteins, we have taken a step forward to address this challenge by cohabitating Immunoglobulin G (IgG1) with a food protein gelatin in the solid-state at room temperature. Interestingly, IgG1 remained functionally active for a record 14 months revealed from the western-blot assay. Further quantification by HP-LC analysis showed 100% structural integrity of IgG1 with no degradation in the gelatin matrix during this period. The developed formulation has a direct application in oral medical nutrition therapy to cure gastrointestinal microbial infections. Also the strategy provides a robust energy economic alternative to the protein engineering methods for long-term functional storage of therapeutic proteins at room temperature.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Materialteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas