Dissolution Rate Enhancement of Parabens in PEG Solid Dispersions and Its Influence on the Release from Hydrophilic Matrix Tablets

Tajarobi, Farhad,1971Chalmers tekniska högskola,Chalmers University of Technology (författare)

The dissolution rate of a homologous series of parabens and their dispersions inPEG 4x103 was examined. In light of these measurements, the release behavior of thesubstances from extended release hydrophilic matrix tablets based on PEO 5x106 was studied.Tablet release was examined for matrices comprising either a physical mixture of PEG, paraben,and PEO, or a solid solution of each paraben in PEG, incorporated in the PEO matrix.Considerable increase of the dissolution rate for the eutectic and in particular solid solutionform of the parabens was observed. The hydration rate of all matrices, as well as polymer release,was the same. The release rate of methyl, ethyl, and butyl parabens in solid solution form wassimilar to that of their crystalline form. However, the release rate of the solid solution form ofpropyl paraben was higher than that of its crystalline form, especially in the initial part of therelease. The results indicate that all parabens crystallized in the gel layer of the solid solutionformulations upon the process of tablet dissolution. This was proposed to be an effect ofdifferences in the dissolution and crystallization kinetics of the parabens.

Abrahmsén-Alami, SusannaAstraZeneca AB (författare)
Larsson, Anette,1966Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)anettel (författare)
Chalmers tekniska högskolaAstraZeneca AB (creator_code:org_t)

Ingår i:Journal of Pharmaceutical Sciences: Elsevier BV100:1, s. 275-2831520-60170022-3549

Av författaren/redakt...: Tajarobi, Farhad ...; Abrahmsén-Alami, ...; Larsson, Anette, ...

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