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Differential Responders to a Mixed Meal Tolerance Test Associated with Type 2 Diabetes Risk Factors and Gut Microbiota—Data from the MEDGI-Carb Randomized Controlled Trial

Skantze, Viktor, 1992 (författare)
Chalmers tekniska högskola,Chalmers University of Technology,Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik (FCC),Fraunhofer-Chalmers Research Centre for Industrial Mathematics (FCC),Fraunhofer-Chalmers Research Centre for Industrial Mathematics, Gothenburg, Sweden; Department of Life Sciences, Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden
Hjorth, Thérése, 1985 (författare)
Chalmers tekniska högskola,Chalmers University of Technology,Department of Life Sciences, Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden
Wallman, Mikael, 1979 (författare)
Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik (FCC),Fraunhofer-Chalmers Research Centre for Industrial Mathematics (FCC),Fraunhofer-Chalmers Research Centre for Industrial Mathematics, Gothenburg, Sweden
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Brunius, Carl, 1974 (författare)
Chalmers tekniska högskola,Chalmers University of Technology,Department of Life Sciences, Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden
Dicksved, Johan (författare)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjurens utfodring och vård (HUV),Department of Animal Nutrition and Management,Sveriges lantbruksuniversitet (SLU),Swedish University of Agricultural Sciences (SLU),Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden
Pelve, Erik A. (författare)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för anatomi, fysiologi och biokemi (AFB),Department of Anatomy, Physiology and Biochemistry (AFB),Sveriges lantbruksuniversitet (SLU),Swedish University of Agricultural Sciences (SLU),Department of Animal Nutrition and Management, Swedish University of Agricultural Sciences, Uppsala, Sweden
Esberg, Anders (författare)
Umeå universitet,Institutionen för odontologi
Vitale, Marilena (författare)
Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II,Diabetes, Nutrition and Metabolism Unit, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy
Giacco, Rosalba (författare)
Consiglo Nazionale Delle Richerche,Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II,Diabetes, Nutrition and Metabolism Unit, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy; Institute of Food Sciences, National Research Council, Avellino, Italy
Costabile, Giuseppina (författare)
Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II,Diabetes, Nutrition and Metabolism Unit, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy
Bergia, Robert E. (författare)
Department of Nutrition Science, Purdue University, IN, West Lafayette, United States
Jirstrand, Mats, 1968 (författare)
Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik (FCC),Fraunhofer-Chalmers Research Centre for Industrial Mathematics (FCC),Fraunhofer-Chalmers Research Centre for Industrial Mathematics, Gothenburg, Sweden
Campbell, Wayne W. (författare)
Department of Nutrition Science, Purdue University, IN, West Lafayette, United States
Riccardi, Gabriele (författare)
Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II,Diabetes, Nutrition and Metabolism Unit, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy
Landberg, Rikard, 1981 (författare)
Chalmers tekniska högskola,Chalmers University of Technology,Department of Life Sciences, Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden
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 (creator_code:org_t)
 
MDPI, 2023
2023
Engelska.
Ingår i: Nutrients. - : MDPI. - 2072-6643 .- 2072-6643. ; 15:20
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https://doi.org/10.3...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The global prevalence of type 2 diabetes mellitus (T2DM) has surged in recent decades, and the identification of differential glycemic responders can aid tailored treatment for the prevention of prediabetes and T2DM. A mixed meal tolerance test (MMTT) based on regular foods offers the potential to uncover differential responders in dynamical postprandial events. We aimed to fit a simple mathematical model on dynamic postprandial glucose data from repeated MMTTs among participants with elevated T2DM risk to identify response clusters and investigate their association with T2DM risk factors and gut microbiota. Data were used from a 12-week multi-center dietary intervention trial involving high-risk T2DM adults, comparing high- versus low-glycemic index foods within a Mediterranean diet context (MEDGICarb). Model-based analysis of MMTTs from 155 participants (81 females and 74 males) revealed two distinct plasma glucose response clusters that were associated with baseline gut microbiota. Cluster A, inversely associated with HbA1c and waist circumference and directly with insulin sensitivity, exhibited a contrasting profile to cluster B. Findings imply that a standardized breakfast MMTT using regular foods could effectively distinguish non-diabetic individuals at varying risk levels for T2DM using a simple mechanistic model.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Nyckelord

differential responders
personalized nutrition
clustering

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