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State-of-the-art me...
State-of-the-art methods for exposure-health studies: Results from the exposome data challenge event
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- Maitre, Léa (author)
- Universitat de Barcelona,University of Barcelona,Universitat Pompeu Fabra,University Pompeu Fabra
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- Guimbaud, Jean Baptiste (author)
- Universitat Pompeu Fabra,University Pompeu Fabra,Universitat de Barcelona,University of Barcelona
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- Warembourg, Charline (author)
- Inserm Transfert SA
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- Güil-Oumrait, Nuria (author)
- Universitat de Barcelona,University of Barcelona,Universitat Pompeu Fabra,University Pompeu Fabra
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- Petrone, Paula Marcela (author)
- Universitat de Barcelona,University of Barcelona
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- Chadeau-Hyam, Marc (author)
- St Mary's Hospital
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- Vrijheid, Martine (author)
- Universitat de Barcelona,University of Barcelona,Universitat Pompeu Fabra,University Pompeu Fabra
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- Basagaña, Xavier (author)
- Universitat de Barcelona,University of Barcelona,Universitat Pompeu Fabra,University Pompeu Fabra
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- Gonzalez, Juan R. (author)
- Universitat Pompeu Fabra,University Pompeu Fabra,Universitat de Barcelona,University of Barcelona
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- Alfano, Rossella (author)
- Universiteit Hasselt
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- Basu, Sanjib (author)
- University of Illinois
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- Benavides, Jaime (author)
- Columbia University in the City of New York
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- Broséus, Lucile (author)
- Université Grenoble Alpes,Grenoble Alpes University
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- Brunius, Carl, 1974 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Caceres, Alejandro (author)
- Universitat de Barcelona,University of Barcelona
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- Carli, Matthew (author)
- Virginia Commonwealth University
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- Cazabet, Rémy (author)
- Universitat de Barcelona,University of Barcelona
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- Chattopadhyay, Shounak (author)
- Duke University
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- Chen, Yun Hua (author)
- University of Illinois
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- Chillrud, Lawrence (author)
- Columbia University in the City of New York
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Conti, David (author)
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- Gennings, Chris (author)
- Icahn School of Medicine at Mount Sinai
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- Gouripeddi, Ramkiran (author)
- University of Utah
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- Iyer, S. Hari (author)
- Harvard University
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- Jedynak, Paulina (author)
- Université Grenoble Alpes,Grenoble Alpes University
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- Li, Huichu (author)
- Harvard University
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- McGee, Glen (author)
- University of Waterloo
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- Midya, Vishal (author)
- Icahn School of Medicine at Mount Sinai
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- Mistry, Sejal (author)
- University of Utah
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- Moccia, Chiara (author)
- Universita degli Studi di Torino,University of Turin
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- Mork, S. Daniel (author)
- Duke University
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Pearce, L. John (author)
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- Peruzzi, Michele (author)
- Duke University
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- Pescador, Jimenez Marcia (author)
- Harvard University
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- Reimann, Brigitte (author)
- Universiteit Hasselt
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- Roscoe, J. Charlotte (author)
- Harvard University
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- Shen, Xiaotao (author)
- Stanford University
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- Stratakis, Nikos (author)
- University of Southern California
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- Wang, Ziyue (author)
- National Institute of Environmental Health Sciences
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- Wang, Congrong (author)
- Universiteit Hasselt
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- Wheeler, David (author)
- Virginia Commonwealth University
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Wilson, Ander (author)
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- Wu, Qiong (author)
- University of Maryland
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- Yu, Miao (author)
- Icahn School of Medicine at Mount Sinai
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Zhao, Yinqi (author)
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- Zou, Fei (author)
- The University of North Carolina,The University of North Carolina System
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- Zugna, Daniela (author)
- Universita degli Studi di Torino,University of Turin
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- Chen, Ruizhe (author)
- University of Illinois
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- Chung, Yu Che (author)
- University of Illinois
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- Jang, Jiyeong (author)
- University of Illinois
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- Turyk, Mary (author)
- University of Illinois
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 168
- Related links:
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https://research.cha... (primary) (free)
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- The exposome recognizes that individuals are exposed simultaneously to a multitude of different environmental factors and takes a holistic approach to the discovery of etiological factors for disease. However, challenges arise when trying to quantify the health effects of complex exposure mixtures. Analytical challenges include dealing with high dimensionality, studying the combined effects of these exposures and their interactions, integrating causal pathways, and integrating high-throughput omics layers. To tackle these challenges, the Barcelona Institute for Global Health (ISGlobal) held a data challenge event open to researchers from all over the world and from all expertises. Analysts had a chance to compete and apply state-of-the-art methods on a common partially simulated exposome dataset (based on real case data from the HELIX project) with multiple correlated exposure variables (P > 100 exposure variables) arising from general and personal environments at different time points, biological molecular data (multi-omics: DNA methylation, gene expression, proteins, metabolomics) and multiple clinical phenotypes in 1301 mother–child pairs. Most of the methods presented included feature selection or feature reduction to deal with the high dimensionality of the exposome dataset. Several approaches explicitly searched for combined effects of exposures and/or their interactions using linear index models or response surface methods, including Bayesian methods. Other methods dealt with the multi-omics dataset in mediation analyses using multiple-step approaches. Here we discuss features of the statistical models used and provide the data and codes used, so that analysts have examples of implementation and can learn how to use these methods. Overall, the exposome data challenge presented a unique opportunity for researchers from different disciplines to create and share state-of-the-art analytical methods, setting a new standard for open science in the exposome and environmental health field.
Subject headings
- NATURVETENSKAP -- Data- och informationsvetenskap -- Annan data- och informationsvetenskap (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Other Computer and Information Science (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Keyword
- Exposome
- Environmental exposures
- Multiple exposures
- Statistical models
- Multi-omics
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Maitre, Léa
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Guimbaud, Jean B ...
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Warembourg, Char ...
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Güil-Oumrait, Nu ...
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Petrone, Paula M ...
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Chadeau-Hyam, Ma ...
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show more...
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Vrijheid, Martin ...
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Basagaña, Xavier
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Gonzalez, Juan R ...
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Alfano, Rossella
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Basu, Sanjib
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Benavides, Jaime
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Broséus, Lucile
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Brunius, Carl, 1 ...
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Caceres, Alejand ...
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Carli, Matthew
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Cazabet, Rémy
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Chattopadhyay, S ...
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Chen, Yun Hua
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Chillrud, Lawren ...
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Conti, David
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Gennings, Chris
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Gouripeddi, Ramk ...
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Iyer, S. Hari
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Jedynak, Paulina
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Li, Huichu
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McGee, Glen
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Midya, Vishal
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Mistry, Sejal
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Moccia, Chiara
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Mork, S. Daniel
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Pearce, L. John
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Peruzzi, Michele
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Pescador, Jimene ...
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Reimann, Brigitt ...
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Roscoe, J. Charl ...
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Shen, Xiaotao
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Stratakis, Nikos
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Wang, Ziyue
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Wang, Congrong
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Wheeler, David
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Wilson, Ander
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Wu, Qiong
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Yu, Miao
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Zhao, Yinqi
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Zou, Fei
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Zugna, Daniela
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Chen, Ruizhe
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Chung, Yu Che
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Jang, Jiyeong
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Turyk, Mary
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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and Other Computer a ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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and Bioinformatics
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Bioinformatics a ...
- Articles in the publication
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Environment Inte ...
- By the university
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Chalmers University of Technology