Meta-Analysis of Adiponectin as a Biomarker for the Detection of Metabolic Syndrome

Liu, ZhengtaoZhejiang University,Ministry of Health of People's Republic of China,Minist Publ Hlth, Key Lab Combined Multiorgan Transplantat, Hangzhou, Zhejiang, Peoples R China.;Key Lab Organ Transplantat Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Div Hepatobiliary & Pancreat Surg, Dept Surg, Affiliated Hosp 1,Sch Med, Hangzhou, Zhejiang, Peoples R China. (författare)

QC 20181001
Previous studies revealed the potential significance of circulating adiponectin levels with respect to the diagnosis and prediction of metabolic syndrome, but uncertainty has been noted across different cohorts. Systematic evaluation was performed for diagnostic accuracy and predictivity of adiponectin variation for metabolic syndrome in enrolled studies including 1,248 and 6,020 subjects, respectively. Adiponectin can identify metabolic syndrome with moderate accuracy (area under the curve = 0.81, 95% CI: 0.77-0.84). Heterogeneity analysis revealed that an increasing index of insulin resistance was independently associated with improving the performance of adiponectin upon metabolic syndrome diagnosis (ratio of diagnostic odds ratio = 3.89, 95% CI: 1.13-13.9). In addition, reductions in adiponectin were associated with increasing metabolic syndrome incidence in a linear dose-response manner. The risk of hypoadiponectinemia with metabolic syndrome was especially increased in men (P < 0.05). Further Mendelian randomization analysis identified that the amplified risk could be attributed to increased susceptibility (up to 7%) to insulin resistance compared with women. In conclusion, adiponectin measurement might have potential benefits in the detection of metabolic syndrome. Factors that affect insulin resistance should be considered for adjustment in future assessments.

Liang, ShuhengWomen & Childrens Hosp Guangxi, Dept Pediat, Nanning, Peoples R China. (författare)
Que, ShupingKTH,Science for Life Laboratory, SciLifeLab(Swepub:kth)PI000000 (författare)
Zhou, LinMinistry of Health of People's Republic of China,Zhejiang University,Minist Publ Hlth, Key Lab Combined Multiorgan Transplantat, Hangzhou, Zhejiang, Peoples R China.;Key Lab Organ Transplantat Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Div Hepatobiliary & Pancreat Surg, Dept Surg, Affiliated Hosp 1,Sch Med, Hangzhou, Zhejiang, Peoples R China. (författare)
Zheng, ShusenMinistry of Health of People's Republic of China,Zhejiang University,Minist Publ Hlth, Key Lab Combined Multiorgan Transplantat, Hangzhou, Zhejiang, Peoples R China.;Key Lab Organ Transplantat Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Div Hepatobiliary & Pancreat Surg, Dept Surg, Affiliated Hosp 1,Sch Med, Hangzhou, Zhejiang, Peoples R China. (författare)
Mardinoglu, Adil,1982KTH,Science for Life Laboratory, SciLifeLab,Chalmers Univ Technol, Dept Biol & Biol Engn, Gothenburg, Sweden.;Kings Coll London, Dent Inst, Ctr Host Microbiome Interact, London, England.(Swepub:kth)u1t8kmr6 (författare)
Zhejiang UniversityMinistry of Health of People's Republic of China (creator_code:org_t)

Av författaren/redakt...: Liu, Zhengtao; Liang, Shuheng; Que, Shuping; Zhou, Lin; Zheng, Shusen; Mardinoglu, Adil ...

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