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Sökning: WFRF:(Kuhn Tilman) > (2022) > Naturvetenskap > Vegan Diet Is Assoc...

  • Prochazkova, Magdalena (författare)

Vegan Diet Is Associated With Favorable Effects on the Metabolic Performance of Intestinal Microbiota: A Cross-Sectional Multi-Omics Study

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-01-07
  • Frontiers Media SA,2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:research.chalmers.se:57c22f24-8db1-42cf-aa0c-e14cb8e2d9f4
  • https://research.chalmers.se/publication/528425URI
  • https://doi.org/10.3389/fnut.2021.783302DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background and Aim: Plant-based diets are associated with potential health benefits, but the contribution of gut microbiota remains to be clarified. We aimed to identify differences in key features of microbiome composition and function with relevance to metabolic health in individuals adhering to a vegan vs. omnivore diet. Methods: This cross-sectional study involved lean, healthy vegans (n = 62) and omnivore (n = 33) subjects. We assessed their glucose and lipid metabolism and employed an integrated multi-omics approach (16S rRNA sequencing, metabolomics profiling) to compare dietary intake, metabolic health, gut microbiome, and fecal, serum, and urine metabolomes. Results: The vegans had more favorable glucose and lipid homeostasis profiles than the omnivores. Long-term reported adherence to a vegan diet affected only 14.8% of all detected bacterial genera in fecal microbiome. However, significant differences in vegan and omnivore metabolomes were observed. In feces, 43.3% of all identified metabolites were significantly different between the vegans and omnivores, such as amino acid fermentation products p-cresol, scatole, indole, methional (lower in the vegans), and polysaccharide fermentation product short- and medium-chain fatty acids (SCFAs, MCFAs), and their derivatives (higher in the vegans). Vegan serum metabolome differed markedly from the omnivores (55.8% of all metabolites), especially in amino acid composition, such as low BCAAs, high SCFAs (formic-, acetic-, propionic-, butyric acids), and dimethylsulfone, the latter two being potential host microbiome co-metabolites. Using a machine-learning approach, we tested the discriminative power of each dataset. Best results were obtained for serum metabolome (accuracy rate 91.6%). Conclusion: While only small differences in the gut microbiota were found between the groups, their metabolic activity differed substantially. In particular, we observed a significantly different abundance of fermentation products associated with protein and carbohydrate intakes in the vegans. Vegans had significantly lower abundances of potentially harmful (such as p-cresol, lithocholic acid, BCAAs, aromatic compounds, etc.) and higher occurrence of potentially beneficial metabolites (SCFAs and their derivatives).

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Budinska, EvaMasarykova Univerzita,Masaryk University (författare)
  • Kuzma, MarekCzech Academy of Sciences (författare)
  • Pelantova, HelenaCzech Academy of Sciences (författare)
  • Hradecky, JaromirČeská zemědělská univerzita v Praze,Czech University of Life Sciences Prague (CULS) (författare)
  • Heczkova, Marie (författare)
  • Daskova, NikolaUniverzita Karlova,Charles University (författare)
  • Bratova, Miriam (författare)
  • Modos, Istvan (författare)
  • Videnska, PetraMasarykova Univerzita,Masaryk University (författare)
  • Splichalova, PetraMasarykova Univerzita,Masaryk University (författare)
  • Sowah, Solomon A.Universitätsklinikum Heidelberg,University Hospital Heidelberg,Deutsches Krebsforschungszentrum (DKFZ),German Cancer Research Center (DKFZ) (författare)
  • Kralova, MariaMasarykova Univerzita,Masaryk University (författare)
  • Henikova, Marina (författare)
  • Selinger, Eliska (författare)
  • Klima, KrystofCzech Academy of Sciences (författare)
  • Chalupsky, KarelCzech Academy of Sciences (författare)
  • Sedlacek, RadislavCzech Academy of Sciences (författare)
  • Landberg, Rikard,1981Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)riklan (författare)
  • Kühn, TilmanUniversitätsklinikum Heidelberg,University Hospital Heidelberg,Queen's University Belfast (författare)
  • Gojda, Jan (författare)
  • Cahova, Monika (författare)
  • Masarykova UniverzitaCzech Academy of Sciences (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Frontiers in Nutrition: Frontiers Media SA82296-861X

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