Synthetic applications of cationic iron and cobalt carbonyl complexes

• Metal carbonyl stabilized cationic species react with a wide range of nucleophiles under mild conditions, and have thus found many synthetic applications. In this Perspective, we describe the utility of iron carbonyl dienyl cations in solution and solid phase parallel synthesis, and in the development of a new synthetic route towards oseltamivir phosphate (Tamiflu). We also discuss the solid phase version of the Nicholas reaction, employing cobalt carbonyl stabilized propargylic cations, and giving access to substituted alkynes.

Subject headings

NATURVETENSKAP  -- Kemi -- Fysikalisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Physical Chemistry (hsv//eng)

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

NATURVETENSKAP  -- Kemi -- Organisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Organic Chemistry (hsv//eng)

Keyword

activity

dicobalt hexacarbonyl

asymmetric catalytic complexation

nicholas

transition-metal-complexes

solid-phase synthesis

pauson-khand reaction

reaction

organic-synthesis

potent antiinfluenza

sonogashira coupling reactions

neuraminidase inhibitor

oseltamivir

complexes

Publication and Content Type

art (subject category)

ref (subject category)